| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 27 | 27 | 9 | 12 | 3.63 | .307 | 1.31 | 9.5 | 2.3 | 10.6 | 173.1 | 183 | 77 | 70 | 18 | 44 | 204 | 0 | 0 | 0 | 0 | 17 | 3 | 4 | 2.81 |
| SP | Nelson, R.Nelson, Ryne >> | 27 | 2025 | R | 82 | 25 | 25 | 6 | 10 | 4.58 | .309 | 1.32 | 8.8 | 3.1 | 7.8 | 123.2 | 120 | 64 | 63 | 18 | 43 | 106 | 0 | 0 | 0 | 0 | 4 | 3 | 2 | 4.30 |
| SP | Luzardo, J.Luzardo, Jesus >> | 27 | 2025 | L | 68 | 25 | 25 | 9 | 8 | 4.36 | .323 | 1.41 | 9.8 | 2.9 | 10.2 | 144.1 | 156 | 72 | 70 | 16 | 47 | 163 | 0 | 0 | 0 | 0 | 13 | 4 | 1 | 3.24 |
| SP | Littell, Z.Littell, Zack >> | 29 | 2025 | R | 65 | 24 | 24 | 10 | 8 | 4.63 | .325 | 1.40 | 10.4 | 2.3 | 8.0 | 147.2 | 170 | 76 | 76 | 23 | 37 | 131 | 0 | 0 | 0 | 0 | 12 | 6 | 1 | 4.13 |
| RP | Svanson, M.Svanson, Matt >> | 26 | 2025 | R | 98 | 67 | 0 | 6 | 4 | 3.64 | .289 | 1.18 | 6.7 | 4.0 | 10.1 | 116.1 | 86 | 47 | 47 | 15 | 51 | 130 | 0 | 5 | 4 | 0 | 0 | 5 | 2 | 3.89 |
| RP | Keller, B.Keller, Brad >> | 29 | 2025 | R | 89 | 63 | 0 | 4 | 2 | 3.83 | .306 | 1.25 | 7.4 | 4.0 | 9.8 | 82.1 | 67 | 36 | 35 | 4 | 36 | 89 | 0 | 4 | 3 | 0 | 0 | 6 | 0 | 3.00 |
| RP | Miller, S.Miller, Shelby >> | 34 | 2025 | R | 83 | 61 | 0 | 6 | 4 | 4.83 | .351 | 1.62 | 8.7 | 5.9 | 10.6 | 69.0 | 67 | 37 | 37 | 5 | 45 | 81 | 0 | 9 | 3 | 0 | 0 | 0 | 3 | 3.55 |
| RP | Strahm, M.Strahm, Matt >> | 33 | 2025 | L | 73 | 48 | 0 | 1 | 1 | 4.24 | .311 | 1.33 | 7.8 | 4.2 | 11.1 | 51.0 | 44 | 24 | 24 | 4 | 24 | 63 | 0 | 5 | 0 | 0 | 0 | 1 | 1 | 3.02 |
| RP | Megill, T.Megill, Trevor >> | 31 | 2025 | R | 71 | 41 | 0 | 2 | 2 | 5.67 | .324 | 1.41 | 8.0 | 4.7 | 9.4 | 46.0 | 41 | 29 | 29 | 7 | 24 | 48 | 0 | 4 | 3 | 0 | 0 | 1 | 5 | 4.52 |
| SP | Pepiot, R.Pepiot, Ryan >> | 27 | 2025 | R | 80 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |