| SP | Arrieta, J.Arrieta, Jake >> | 30 | 2016 | R | 81 | 30 | 30 | 13 | 10 | 4.14 | .308 | 1.32 | 8.0 | 3.8 | 6.3 | 189.1 | 169 | 91 | 87 | 15 | 80 | 133 | 0 | 0 | 0 | 0 | 19 | 4 | 9 | 3.96 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 90 | 30 | 30 | 19 | 4 | 2.24 | .240 | 0.93 | 6.3 | 2.1 | 6.0 | 213.1 | 148 | 58 | 53 | 23 | 50 | 141 | 3 | 0 | 0 | 0 | 25 | 4 | 2 | 3.84 |
| SP | Lackey, J.Lackey, John >> | 38 | 2016 | R | 80 | 29 | 29 | 10 | 11 | 3.64 | .295 | 1.23 | 7.7 | 3.4 | 6.6 | 185.1 | 159 | 85 | 75 | 24 | 69 | 135 | 0 | 0 | 0 | 0 | 21 | 5 | 2 | 4.43 |
| SP | Hammel, J.Hammel, Jason >> | 34 | 2016 | R | 42 | 29 | 29 | 11 | 4 | 5.18 | .328 | 1.45 | 9.3 | 3.8 | 6.8 | 154.2 | 159 | 89 | 89 | 20 | 65 | 116 | 0 | 0 | 0 | 0 | 11 | 2 | 7 | 4.49 |
| CL | Chapman, A.Chapman, Aroldis >> | 28 | 2016 | L | 93 | 64 | 0 | 3 | 8 | 3.32 | .247 | 0.97 | 6.5 | 2.2 | 10.5 | 65.0 | 47 | 25 | 24 | 10 | 16 | 76 | 0 | 34 | 6 | 0 | 0 | 1 | 4 | 3.45 |
| RP | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 98 | 90 | 0 | 3 | 2 | 2.26 | .255 | 1.01 | 5.0 | 4.2 | 10.1 | 91.2 | 51 | 24 | 23 | 8 | 42 | 102 | 0 | 5 | 0 | 0 | 0 | 1 | 3 | 3.32 |
| RP | Rondon, H.Rondon, Hector >> | 28 | 2016 | R | 63 | 46 | 0 | 5 | 3 | 2.77 | .247 | 0.95 | 6.0 | 2.6 | 10.3 | 48.2 | 32 | 18 | 15 | 5 | 14 | 55 | 0 | 1 | 1 | 0 | 0 | 2 | 2 | 3.06 |
| RP | Montgomery, M.Montgomery, Mike >> | 26 | 2016 | L | 47 | 63 | 0 | 3 | 2 | 1.47 | .236 | 0.89 | 5.1 | 2.9 | 5.1 | 55.0 | 31 | 9 | 9 | 3 | 18 | 31 | 0 | 4 | 1 | 0 | 0 | 2 | 2 | 3.67 |
| RP | Cahill, T.Cahill, Trevor >> | 28 | 2016 | R | 42 | 46 | 0 | 2 | 2 | 3.20 | .297 | 1.24 | 5.6 | 5.6 | 10.8 | 45.0 | 28 | 17 | 16 | 7 | 28 | 54 | 0 | 1 | 1 | 0 | 0 | 1 | 2 | 4.56 |