| SP | deGrom, J.deGrom, Jacob # >> | 33 | 2021 | R | 100 | 29 | 29 | 11 | 8 | 3.64 | .282 | 1.14 | 7.2 | 3.0 | 10.1 | 190.1 | 153 | 80 | 77 | 17 | 64 | 213 | 0 | 0 | 0 | 0 | 21 | 7 | 0 | 3.04 |
| SP | Kluber, C.Kluber, Corey # >> | 31 | 2017 | R | 89 | 28 | 28 | 6 | 15 | 4.53 | .303 | 1.29 | 8.4 | 3.3 | 7.9 | 194.2 | 180 | 101 | 98 | 25 | 71 | 170 | 3 | 0 | 0 | 1 | 13 | 3 | 4 | 4.07 |
| SP | Nelson, R.Nelson, Roger # >> | 28 | 1972 | R | 84 | 27 | 27 | 6 | 10 | 6.00 | .345 | 1.52 | 10.1 | 3.6 | 4.7 | 141.0 | 158 | 100 | 94 | 20 | 56 | 74 | 0 | 0 | 0 | 0 | 6 | 9 | 4 | 5.18 |
| SP | Marichal, J.Marichal, Juan # >> | 29 | 1966 | R | 76 | 27 | 27 | 12 | 11 | 5.56 | .339 | 1.53 | 10.7 | 3.0 | 4.2 | 183.0 | 218 | 120 | 113 | 29 | 62 | 85 | 4 | 0 | 0 | 1 | 9 | 2 | 4 | 5.18 |
| SP | Cicotte, E.Cicotte, Eddie # >> | 33 | 1917 | R | 74 | 27 | 27 | 11 | 12 | 4.95 | .323 | 1.42 | 9.7 | 3.1 | 4.2 | 192.2 | 207 | 107 | 106 | 21 | 67 | 90 | 3 | 0 | 0 | 0 | 13 | 2 | 2 | 4.56 |
| CL | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 57 | 0 | 1 | 9 | 4.22 | .286 | 1.14 | 7.6 | 2.7 | 8.5 | 53.1 | 45 | 26 | 25 | 7 | 16 | 50 | 0 | 30 | 6 | 0 | 0 | 3 | 0 | 3.91 |
| SU | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 57 | 0 | 2 | 1 | 1.20 | .265 | 1.03 | 5.4 | 3.9 | 9.5 | 60.0 | 36 | 8 | 8 | 0 | 26 | 63 | 0 | 3 | 2 | 0 | 0 | 3 | 3 | 2.35 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 75 | 0 | 5 | 2 | 3.11 | .270 | 1.10 | 7.9 | 2.0 | 8.6 | 66.2 | 58 | 26 | 23 | 6 | 15 | 63 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 3.00 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 73 | 0 | 4 | 1 | 2.72 | .287 | 1.19 | 6.6 | 4.2 | 7.7 | 49.2 | 36 | 18 | 15 | 4 | 23 | 42 | 0 | 1 | 1 | 0 | 0 | 1 | 3 | 3.82 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 56 | 0 | 1 | 5 | 4.30 | .307 | 1.31 | 7.0 | 5.0 | 4.0 | 58.2 | 45 | 29 | 28 | 9 | 32 | 26 | 0 | 3 | 1 | 0 | 0 | 1 | 0 | 5.83 |