| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 35 | 35 | 11 | 11 | 4.99 | .328 | 1.45 | 9.7 | 3.4 | 9.3 | 223.2 | 240 | 127 | 124 | 26 | 84 | 230 | 2 | 0 | 0 | 2 | 17 | 3 | 6 | 3.62 |
| SP | Koufax, S.Koufax, Sandy † >> | 30 | 1965 | L | 97 | 34 | 34 | 15 | 17 | 3.38 | .289 | 1.19 | 8.0 | 2.7 | 9.1 | 264.0 | 236 | 114 | 99 | 22 | 79 | 268 | 12 | 0 | 0 | 3 | 23 | 7 | 5 | 3.03 |
| SP | Johnson, W.Johnson, Walter # >> | 26 | 1913 | R | 95 | 33 | 33 | 16 | 11 | 4.38 | .297 | 1.24 | 9.2 | 2.0 | 4.6 | 242.2 | 248 | 134 | 118 | 26 | 53 | 124 | 6 | 0 | 0 | 0 | 18 | 6 | 6 | 4.10 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 33 | 33 | 13 | 15 | 4.94 | .332 | 1.46 | 9.3 | 3.9 | 8.9 | 227.2 | 234 | 132 | 125 | 31 | 99 | 224 | 4 | 0 | 0 | 1 | 14 | 6 | 7 | 4.19 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 95 | 98 | 0 | 10 | 3 | 3.35 | .281 | 1.15 | 7.2 | 3.2 | 8.2 | 91.1 | 73 | 36 | 34 | 14 | 32 | 83 | 0 | 7 | 2 | 0 | 0 | 2 | 2 | 4.30 |
| RP | Gregerson, L.Gregerson, Luke # >> | 26 | 2010 | R | 73 | 60 | 0 | 6 | 0 | 3.08 | .324 | 1.42 | 7.5 | 5.3 | 7.5 | 61.1 | 51 | 21 | 21 | 3 | 36 | 51 | 0 | 12 | 4 | 0 | 0 | 1 | 0 | 3.79 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 33 | 0 | 2 | 3 | 5.97 | .350 | 1.59 | 10.9 | 3.7 | 6.9 | 34.2 | 41 | 23 | 23 | 8 | 14 | 26 | 0 | 5 | 1 | 0 | 0 | 1 | 2 | 5.85 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 69 | 25 | 0 | 1 | 0 | 9.23 | .388 | 1.90 | 14.5 | 2.8 | 4.8 | 26.1 | 42 | 30 | 27 | 6 | 8 | 14 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 5.85 |