| SP | Martinez, P.Martinez, Pedro † >> | 29 | 2000 | R | 100 | 29 | 29 | 14 | 6 | 2.05 | .231 | 0.88 | 6.2 | 1.7 | 7.9 | 224.1 | 154 | 53 | 51 | 12 | 43 | 196 | 4 | 0 | 0 | 2 | 24 | 5 | 1 | 2.59 |
| SP | Tiant, L.Tiant, Luis # >> | 28 | 1968 | R | 97 | 28 | 28 | 15 | 4 | 3.37 | .265 | 1.07 | 7.3 | 2.3 | 7.0 | 195.0 | 158 | 73 | 73 | 17 | 50 | 152 | 1 | 0 | 0 | 0 | 19 | 3 | 4 | 3.39 |
| SP | McNally, D.McNally, Dave >> | 26 | 1968 | L | 96 | 28 | 28 | 10 | 11 | 3.62 | .305 | 1.31 | 8.3 | 3.6 | 4.3 | 208.2 | 191 | 99 | 84 | 15 | 83 | 100 | 6 | 0 | 0 | 1 | 17 | 1 | 5 | 4.19 |
| SP | Krause, H.Krause, Harry # >> | 21 | 1909 | L | 71 | 26 | 26 | 10 | 12 | 4.77 | .314 | 1.37 | 9.4 | 2.9 | 4.6 | 166.0 | 174 | 88 | 88 | 18 | 53 | 85 | 0 | 0 | 0 | 0 | 12 | 1 | 2 | 4.36 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 98 | 61 | 0 | 5 | 8 | 2.40 | .260 | 1.05 | 5.4 | 4.1 | 10.3 | 63.2 | 38 | 17 | 17 | 4 | 29 | 72 | 0 | 42 | 5 | 0 | 0 | 0 | 1 | 2.92 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 80 | 0 | 2 | 5 | 3.54 | .249 | 0.98 | 6.6 | 2.3 | 10.2 | 81.1 | 59 | 32 | 32 | 13 | 21 | 92 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 3.63 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 90 | 39 | 0 | 4 | 1 | 2.66 | .286 | 1.18 | 5.9 | 4.7 | 7.2 | 44.0 | 29 | 13 | 13 | 4 | 23 | 35 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 4.23 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 20 | 0 | 0 | 0 | 0.44 | .247 | 0.93 | 6.3 | 2.3 | 6.8 | 20.1 | 14 | 1 | 1 | 1 | 5 | 15 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.05 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 14 | 0 | 2 | 1 | 1.76 | .246 | 0.98 | 7.2 | 1.8 | 7.2 | 15.1 | 12 | 3 | 3 | 1 | 3 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.87 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 60 | 14 | 0 | 2 | 3 | 4.37 | .335 | 1.47 | 8.0 | 5.4 | 7.4 | 55.2 | 49 | 27 | 27 | 12 | 33 | 45 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 6.11 |