| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 31 | 31 | 12 | 12 | 3.57 | .287 | 1.18 | 7.1 | 3.5 | 4.7 | 184.0 | 146 | 81 | 73 | 18 | 72 | 97 | 1 | 0 | 0 | 1 | 20 | 4 | 1 | 4.46 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 31 | 31 | 9 | 14 | 4.15 | .275 | 1.11 | 8.5 | 1.5 | 6.3 | 195.1 | 184 | 99 | 90 | 24 | 33 | 136 | 2 | 0 | 0 | 1 | 18 | 5 | 1 | 3.79 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 31 | 30 | 9 | 14 | 4.36 | .301 | 1.28 | 9.3 | 2.3 | 4.7 | 187.2 | 194 | 94 | 91 | 17 | 47 | 97 | 3 | 0 | 0 | 1 | 15 | 2 | 3 | 3.93 |
| SP | Fernandez, J.Fernandez, Jose # >> | 21 | 2013 | R | 76 | 31 | 30 | 8 | 8 | 4.55 | .287 | 1.20 | 7.8 | 2.9 | 8.5 | 168.0 | 146 | 87 | 85 | 27 | 55 | 159 | 3 | 0 | 0 | 1 | 17 | 2 | 1 | 4.21 |
| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 43 | 32 | 28 | 12 | 7 | 4.21 | .308 | 1.32 | 7.9 | 3.9 | 3.4 | 196.2 | 173 | 97 | 92 | 18 | 86 | 73 | 3 | 0 | 1 | 0 | 13 | 3 | 7 | 4.81 |
| RP | Balfour, G.Balfour, Grant † >> | 31 | 2008 | R | 76 | 90 | 0 | 12 | 3 | 2.49 | .262 | 1.04 | 5.7 | 3.6 | 9.5 | 112.0 | 71 | 37 | 31 | 9 | 45 | 118 | 0 | 3 | 2 | 0 | 0 | 3 | 1 | 3.22 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 58 | 70 | 0 | 6 | 4 | 3.43 | .302 | 1.28 | 6.3 | 5.3 | 5.9 | 115.1 | 80 | 51 | 44 | 7 | 68 | 75 | 0 | 5 | 3 | 0 | 0 | 2 | 3 | 4.31 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 73 | 52 | 0 | 3 | 1 | 3.06 | .257 | 1.02 | 5.9 | 3.2 | 9.3 | 53.0 | 35 | 19 | 18 | 3 | 19 | 55 | 0 | 1 | 1 | 0 | 0 | 1 | 3 | 2.79 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 41 | 0 | 3 | 0 | 3.51 | .267 | 1.09 | 6.5 | 3.4 | 9.7 | 51.1 | 37 | 21 | 20 | 8 | 19 | 55 | 0 | 2 | 2 | 0 | 0 | 0 | 1 | 4.00 |
| CL | Marmol, C.Marmol, Carlos † >> | 26 | 2008 | R | 71 | 70 | 0 | 8 | 5 | 2.22 | .264 | 1.06 | 4.6 | 5.0 | 7.5 | 77.0 | 39 | 20 | 19 | 6 | 43 | 64 | 0 | 31 | 2 | 0 | 0 | 1 | 0 | 4.06 |