| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 32 | 32 | 14 | 11 | 3.92 | .306 | 1.31 | 8.8 | 3.0 | 8.2 | 218.0 | 214 | 103 | 95 | 22 | 72 | 198 | 2 | 0 | 0 | 0 | 21 | 2 | 3 | 3.51 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 32 | 32 | 15 | 9 | 3.85 | .309 | 1.33 | 8.0 | 4.0 | 5.5 | 194.0 | 172 | 96 | 83 | 11 | 86 | 118 | 2 | 0 | 0 | 0 | 14 | 2 | 3 | 3.88 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 82 | 31 | 31 | 14 | 10 | 4.47 | .316 | 1.36 | 9.9 | 2.3 | 5.7 | 203.1 | 224 | 111 | 101 | 24 | 52 | 128 | 8 | 0 | 0 | 2 | 17 | 6 | 0 | 4.13 |
| SP | Reulbach, E.Reulbach, Ed >> | 23 | 1905 | R | 64 | 31 | 31 | 4 | 20 | 7.46 | .376 | 1.79 | 12.0 | 4.1 | 4.8 | 175.0 | 233 | 161 | 145 | 36 | 80 | 94 | 2 | 0 | 0 | 0 | 6 | 3 | 2 | 6.02 |
| SP | McDowell, S.McDowell, Sam >> | 23 | 1965 | L | 44 | 29 | 29 | 12 | 9 | 5.72 | .366 | 1.71 | 10.1 | 5.3 | 7.7 | 162.0 | 181 | 115 | 103 | 28 | 96 | 138 | 1 | 0 | 0 | 0 | 10 | 3 | 11 | 5.38 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 90 | 72 | 0 | 4 | 3 | 3.12 | .309 | 1.34 | 8.7 | 3.4 | 8.8 | 95.1 | 92 | 38 | 33 | 14 | 36 | 93 | 0 | 1 | 3 | 0 | 0 | 0 | 3 | 4.09 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 69 | 0 | 5 | 2 | 3.61 | .324 | 1.41 | 7.9 | 4.9 | 8.6 | 72.1 | 63 | 38 | 29 | 5 | 39 | 69 | 0 | 2 | 3 | 0 | 0 | 2 | 2 | 3.69 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 68 | 48 | 0 | 3 | 2 | 2.92 | .321 | 1.42 | 8.1 | 4.8 | 6.4 | 49.1 | 44 | 17 | 16 | 7 | 26 | 35 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 5.02 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 66 | 34 | 0 | 4 | 1 | 3.27 | .293 | 1.24 | 9.0 | 2.2 | 5.7 | 33.0 | 33 | 13 | 12 | 4 | 8 | 21 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.03 |