| SP | McNally, D.McNally, Dave >> | 26 | 1968 | L | 96 | 34 | 34 | 13 | 16 | 4.31 | .288 | 1.20 | 7.7 | 3.1 | 5.3 | 246.2 | 211 | 129 | 118 | 33 | 84 | 145 | 11 | 0 | 0 | 3 | 15 | 5 | 4 | 4.65 |
| SP | Waddell, R.Waddell, Rube # >> | 29 | 1905 | L | 67 | 32 | 32 | 7 | 19 | 5.15 | .327 | 1.45 | 9.8 | 3.3 | 6.2 | 206.1 | 224 | 122 | 118 | 25 | 75 | 142 | 3 | 0 | 0 | 3 | 14 | 2 | 3 | 4.32 |
| SP | Harden, R.Harden, Rich # >> | 27 | 2008 | R | 61 | 32 | 32 | 5 | 14 | 6.12 | .352 | 1.61 | 10.1 | 4.4 | 8.2 | 142.2 | 160 | 97 | 97 | 26 | 69 | 129 | 0 | 0 | 0 | 0 | 3 | 3 | 0 | 5.08 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 60 | 31 | 30 | 9 | 16 | 5.56 | .331 | 1.46 | 10.4 | 2.7 | 5.1 | 200.2 | 231 | 132 | 124 | 30 | 61 | 114 | 9 | 0 | 0 | 2 | 10 | 6 | 3 | 4.82 |
| RP | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 94 | 79 | 0 | 4 | 3 | 4.15 | .304 | 1.29 | 6.9 | 4.8 | 10.7 | 97.2 | 74 | 48 | 45 | 6 | 52 | 115 | 0 | 5 | 2 | 0 | 0 | 2 | 9 | 3.10 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 68 | 68 | 0 | 7 | 2 | 3.35 | .285 | 1.15 | 5.8 | 4.5 | 6.4 | 91.1 | 59 | 39 | 34 | 9 | 46 | 65 | 0 | 2 | 2 | 0 | 0 | 4 | 2 | 4.51 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 60 | 65 | 0 | 5 | 1 | 3.61 | .307 | 1.32 | 8.4 | 3.5 | 7.5 | 77.1 | 72 | 32 | 31 | 11 | 30 | 64 | 0 | 5 | 3 | 0 | 0 | 1 | 0 | 4.40 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 7 | 1 | 1 | 0 | 4.91 | .343 | 1.50 | 10.3 | 3.9 | 7.7 | 14.2 | 16 | 8 | 8 | 3 | 6 | 12 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 5.57 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 51 | 39 | 0 | 5 | 6 | 6.10 | .342 | 1.54 | 11.5 | 2.4 | 5.8 | 82.2 | 105 | 62 | 56 | 12 | 22 | 53 | 0 | 4 | 2 | 0 | 0 | 2 | 4 | 4.49 |