| SP | Koufax, S.Koufax, Sandy † >> | 30 | 1965 | L | 97 | 34 | 34 | 16 | 11 | 3.44 | .297 | 1.23 | 8.0 | 3.1 | 7.8 | 267.0 | 236 | 112 | 102 | 27 | 93 | 232 | 14 | 0 | 0 | 1 | 22 | 9 | 3 | 3.72 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 30 | 30 | 6 | 17 | 5.77 | .356 | 1.63 | 11.1 | 3.6 | 4.6 | 187.1 | 230 | 132 | 120 | 31 | 75 | 96 | 4 | 0 | 0 | 1 | 9 | 5 | 5 | 5.41 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 31 | 31 | 11 | 12 | 4.94 | .337 | 1.48 | 9.7 | 3.6 | 5.1 | 195.0 | 211 | 118 | 107 | 26 | 78 | 111 | 1 | 0 | 0 | 1 | 15 | 8 | 4 | 4.92 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 80 | 0 | 5 | 3 | 3.01 | .270 | 1.09 | 6.2 | 3.7 | 7.9 | 110.2 | 76 | 40 | 37 | 13 | 45 | 96 | 0 | 3 | 2 | 0 | 0 | 2 | 1 | 4.07 |
| RP | Hochevar, L.Hochevar, Luke # >> | 30 | 2013 | R | 78 | 79 | 0 | 7 | 5 | 5.42 | .307 | 1.32 | 8.9 | 3.0 | 8.2 | 103.0 | 102 | 64 | 62 | 23 | 34 | 94 | 0 | 9 | 9 | 0 | 0 | 1 | 5 | 5.10 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 67 | 59 | 0 | 2 | 1 | 2.79 | .298 | 1.27 | 7.5 | 4.0 | 6.9 | 61.1 | 51 | 20 | 19 | 10 | 27 | 47 | 0 | 4 | 2 | 0 | 0 | 0 | 4 | 4.92 |
| RP | Smoltz, J.Smoltz, John >> | 36 | 2003 | R | 52 | 46 | 0 | 1 | 1 | 5.56 | .358 | 1.65 | 11.4 | 3.6 | 8.6 | 45.1 | 57 | 28 | 28 | 8 | 18 | 43 | 0 | 9 | 2 | 0 | 0 | 1 | 0 | 4.67 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 2 | 2 | 0 | 0 | 8.44 | .396 | 1.97 | 12.6 | 6.3 | 8.1 | 10.2 | 14 | 10 | 10 | 3 | 7 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 7.20 |
| SP | Camnitz, H.Camnitz, Howie >> | 28 | 1909 | R | 58 | 4 | 0 | 0 | 0 | 1.69 | .304 | 1.31 | 9.0 | 3.6 | 10.8 | 5.1 | 5 | 1 | 1 | 0 | 2 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.80 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 20 | 0 | 5 | 4 | 7.93 | .370 | 1.76 | 12.5 | 3.5 | 4.8 | 36.1 | 50 | 34 | 32 | 3 | 14 | 19 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 4.19 |