| SP | Tiant, L.Tiant, Luis † >> | 28 | 1968 | R | 97 | 34 | 34 | 18 | 9 | 3.22 | .281 | 1.15 | 6.9 | 3.4 | 7.5 | 223.1 | 172 | 86 | 80 | 30 | 84 | 185 | 2 | 0 | 0 | 0 | 24 | 6 | 5 | 4.30 |
| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 33 | 33 | 17 | 7 | 3.20 | .276 | 1.12 | 6.7 | 3.5 | 8.1 | 213.2 | 158 | 79 | 76 | 22 | 82 | 191 | 2 | 0 | 0 | 1 | 24 | 4 | 2 | 3.76 |
| SP | Mathewson, C.Mathewson, Christy † >> | 28 | 1908 | R | 83 | 32 | 32 | 19 | 8 | 3.40 | .282 | 1.18 | 8.4 | 2.2 | 4.4 | 214.2 | 200 | 87 | 81 | 18 | 53 | 105 | 6 | 0 | 0 | 2 | 22 | 0 | 3 | 3.86 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 31 | 31 | 15 | 3 | 3.81 | .280 | 1.16 | 7.0 | 3.4 | 7.5 | 196.0 | 153 | 87 | 83 | 23 | 75 | 164 | 1 | 0 | 0 | 0 | 20 | 1 | 4 | 4.02 |
| CL | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 81 | 0 | 9 | 7 | 2.44 | .267 | 1.09 | 7.0 | 2.9 | 8.5 | 85.0 | 66 | 23 | 23 | 4 | 27 | 80 | 0 | 54 | 3 | 0 | 0 | 0 | 0 | 2.68 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 42 | 0 | 2 | 3 | 3.19 | .294 | 1.21 | 6.8 | 4.1 | 8.8 | 48.0 | 36 | 18 | 17 | 4 | 22 | 47 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 3.63 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 17 | 0 | 5 | 0 | 2.43 | .263 | 1.06 | 6.3 | 3.3 | 6.7 | 77.2 | 54 | 24 | 21 | 5 | 28 | 57 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.49 |