| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 6 | 6 | 2 | 2 | 2.41 | .263 | 1.07 | 7.2 | 2.4 | 9.0 | 41.0 | 33 | 12 | 11 | 5 | 11 | 41 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | 3.39 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 6 | 6 | 2 | 3 | 6.82 | .321 | 1.39 | 10.2 | 2.6 | 7.8 | 31.2 | 35 | 24 | 24 | 6 | 9 | 27 | 0 | 0 | 0 | 0 | 3 | 1 | 0 | 4.74 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 6 | 6 | 1 | 5 | 5.35 | .356 | 1.66 | 10.7 | 4.5 | 5.9 | 38.2 | 45 | 26 | 23 | 8 | 19 | 25 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 5.92 |
| SP | Schmidt, J.Schmidt, Jason # >> | 30 | 2003 | R | 67 | 6 | 6 | 3 | 2 | 5.18 | .335 | 1.51 | 11.0 | 2.9 | 7.7 | 41.2 | 50 | 27 | 24 | 6 | 13 | 35 | 1 | 0 | 0 | 0 | 3 | 0 | 0 | 4.15 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 5 | 5 | 3 | 1 | 3.59 | .308 | 1.34 | 8.8 | 3.4 | 4.3 | 42.2 | 41 | 17 | 17 | 2 | 16 | 20 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 3.81 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 16 | 0 | 0 | 0 | 4.19 | .256 | 1.03 | 8.1 | 1.4 | 11.4 | 19.1 | 17 | 9 | 9 | 6 | 3 | 24 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 5.05 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 12 | 0 | 1 | 0 | 1.98 | .339 | 1.54 | 12.5 | 2.1 | 13.2 | 13.2 | 18 | 3 | 3 | 1 | 3 | 19 | 0 | 1 | 3 | 0 | 0 | 0 | 0 | 1.77 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 9 | 0 | 0 | 2 | 4.91 | .283 | 1.18 | 4.9 | 5.7 | 7.4 | 11.0 | 6 | 6 | 6 | 3 | 7 | 9 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 6.82 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 8 | 0 | 1 | 1 | 6.75 | .412 | 2.10 | 13.5 | 7.5 | 9.0 | 6.2 | 9 | 6 | 5 | 2 | 5 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7.83 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 58 | 5 | 0 | 0 | 0 | 6.75 | .385 | 1.88 | 12.6 | 5.4 | 10.8 | 5.1 | 7 | 5 | 4 | 2 | 3 | 6 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 7.60 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 60 | 1 | 0 | 0 | 0 | 6.75 | .368 | 1.75 | 11.3 | 4.5 | 6.8 | 4.0 | 5 | 3 | 3 | 2 | 2 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 9.50 |