| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 34 | 34 | 12 | 7 | 2.94 | .267 | 1.08 | 7.7 | 2.0 | 9.1 | 235.1 | 201 | 82 | 77 | 31 | 53 | 237 | 0 | 0 | 0 | 0 | 22 | 3 | 0 | 3.41 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 33 | 33 | 10 | 14 | 4.81 | .319 | 1.39 | 9.4 | 3.2 | 8.9 | 194.2 | 203 | 110 | 104 | 31 | 68 | 191 | 0 | 0 | 0 | 0 | 15 | 3 | 3 | 4.21 |
| SP | Cueto, J.Cueto, Johnny # >> | 28 | 2014 | R | 75 | 32 | 32 | 9 | 20 | 5.14 | .338 | 1.51 | 9.5 | 4.0 | 6.5 | 219.0 | 232 | 135 | 125 | 44 | 98 | 158 | 8 | 0 | 0 | 1 | 9 | 5 | 5 | 5.58 |
| SP | Schmidt, J.Schmidt, Jason # >> | 30 | 2003 | R | 67 | 32 | 32 | 15 | 11 | 4.88 | .313 | 1.35 | 9.7 | 2.4 | 7.6 | 230.1 | 249 | 131 | 125 | 36 | 62 | 193 | 8 | 0 | 0 | 0 | 15 | 4 | 5 | 4.22 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 31 | 31 | 13 | 15 | 4.64 | .326 | 1.44 | 9.6 | 3.4 | 4.8 | 246.1 | 263 | 135 | 127 | 23 | 92 | 131 | 9 | 0 | 0 | 0 | 12 | 3 | 6 | 4.31 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 82 | 0 | 2 | 3 | 3.75 | .277 | 1.09 | 7.8 | 2.1 | 8.6 | 108.0 | 93 | 47 | 45 | 17 | 25 | 103 | 0 | 13 | 3 | 0 | 0 | 6 | 3 | 4.00 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 70 | 0 | 6 | 4 | 3.64 | .288 | 1.21 | 8.9 | 2.1 | 9.7 | 81.2 | 80 | 34 | 33 | 8 | 19 | 87 | 0 | 7 | 7 | 0 | 0 | 0 | 1 | 2.84 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 44 | 0 | 2 | 6 | 3.54 | .286 | 1.16 | 6.5 | 4.1 | 8.5 | 53.1 | 38 | 23 | 21 | 10 | 24 | 50 | 0 | 3 | 0 | 0 | 0 | 2 | 1 | 5.04 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 33 | 0 | 2 | 4 | 5.46 | .352 | 1.60 | 8.7 | 5.8 | 9.3 | 31.1 | 30 | 23 | 19 | 6 | 20 | 32 | 0 | 3 | 3 | 0 | 0 | 1 | 2 | 5.48 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 58 | 37 | 0 | 2 | 1 | 3.18 | .303 | 1.29 | 6.6 | 5.1 | 6.9 | 56.2 | 41 | 21 | 20 | 6 | 32 | 43 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 4.63 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 60 | 11 | 0 | 1 | 3 | 4.50 | .355 | 1.65 | 9.0 | 5.9 | 5.0 | 20.0 | 20 | 14 | 10 | 3 | 13 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.80 |