| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 6 | 6 | 1 | 3 | 4.14 | .319 | 1.40 | 10.1 | 2.6 | 6.8 | 41.1 | 46 | 23 | 19 | 8 | 12 | 31 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 4.90 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 79 | 6 | 6 | 3 | 2 | 2.95 | .325 | 1.39 | 10.0 | 2.8 | 7.0 | 36.2 | 40 | 13 | 12 | 4 | 11 | 28 | 1 | 0 | 0 | 1 | 4 | 2 | 1 | 3.97 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 74 | 6 | 6 | 4 | 1 | 2.85 | .304 | 1.29 | 9.2 | 2.5 | 4.8 | 47.1 | 48 | 18 | 15 | 7 | 13 | 25 | 1 | 0 | 0 | 0 | 5 | 1 | 1 | 4.77 |
| SP | Clemens, R.Clemens, Roger # >> | 24 | 1986 | R | 69 | 5 | 5 | 1 | 1 | 5.97 | .348 | 1.60 | 11.9 | 2.9 | 4.8 | 28.2 | 37 | 19 | 19 | 5 | 9 | 15 | 1 | 0 | 0 | 0 | 2 | 0 | 1 | 5.21 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 95 | 14 | 0 | 1 | 1 | 5.65 | .317 | 1.40 | 9.0 | 3.9 | 5.8 | 14.1 | 14 | 11 | 9 | 4 | 6 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.71 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 4 | 0 | 0 | 1 | 6.23 | .458 | 2.54 | 11.3 | 13.5 | 11.3 | 4.1 | 5 | 3 | 3 | 0 | 6 | 5 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 5.00 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 5 | 0 | 0 | 0 | 1.17 | .207 | 0.78 | 6.4 | 1.3 | 2.6 | 7.2 | 5 | 1 | 1 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.86 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 14 | 0 | 0 | 4 | 6.75 | .400 | 2.00 | 14.3 | 3.8 | 9.0 | 12.0 | 19 | 10 | 9 | 4 | 5 | 12 | 0 | 7 | 3 | 0 | 0 | 0 | 0 | 6.58 |