| SP | Kershaw, C.Kershaw, Clayton # >> | 28 | 2016 | L | 99 | 34 | 34 | 16 | 13 | 4.09 | .281 | 1.17 | 8.7 | 1.8 | 9.2 | 233.0 | 226 | 114 | 106 | 28 | 46 | 238 | 6 | 0 | 0 | 2 | 21 | 1 | 3 | 3.12 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 31 | 27 | 6 | 12 | 6.29 | .342 | 1.54 | 10.8 | 3.1 | 5.1 | 140.1 | 168 | 106 | 98 | 26 | 48 | 80 | 0 | 0 | 1 | 0 | 4 | 3 | 7 | 5.36 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 32 | 32 | 12 | 12 | 4.57 | .318 | 1.39 | 9.2 | 3.4 | 4.0 | 228.2 | 232 | 121 | 116 | 30 | 85 | 102 | 6 | 0 | 0 | 2 | 13 | 3 | 2 | 4.97 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 31 | 31 | 9 | 8 | 5.72 | .324 | 1.43 | 9.8 | 3.1 | 7.8 | 184.0 | 200 | 123 | 117 | 40 | 64 | 159 | 0 | 0 | 0 | 0 | 10 | 0 | 4 | 5.14 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 74 | 0 | 3 | 3 | 3.93 | .309 | 1.32 | 8.5 | 3.5 | 8.2 | 91.2 | 86 | 45 | 40 | 7 | 35 | 83 | 0 | 1 | 2 | 0 | 0 | 2 | 1 | 3.40 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 42 | 0 | 2 | 4 | 2.97 | .314 | 1.35 | 7.5 | 4.8 | 10.8 | 36.1 | 30 | 12 | 12 | 6 | 19 | 43 | 0 | 1 | 1 | 0 | 0 | 1 | 4 | 4.44 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 85 | 24 | 0 | 4 | 0 | 5.40 | .302 | 1.30 | 8.7 | 3.0 | 8.7 | 30.0 | 29 | 18 | 18 | 5 | 10 | 29 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 4.23 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 78 | 20 | 0 | 0 | 0 | 2.75 | .306 | 1.32 | 8.1 | 4.3 | 9.0 | 19.2 | 17 | 8 | 6 | 2 | 9 | 19 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.79 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 72 | 28 | 0 | 0 | 1 | 5.57 | .331 | 1.48 | 9.0 | 4.5 | 9.3 | 32.1 | 32 | 21 | 20 | 5 | 16 | 33 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 4.47 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 70 | 25 | 6 | 6 | 8 | 5.13 | .336 | 1.45 | 8.2 | 4.9 | 5.5 | 128.0 | 116 | 81 | 73 | 17 | 70 | 78 | 1 | 0 | 0 | 0 | 3 | 8 | 3 | 5.34 |
| CL | Rivera, M.Rivera, Mariano † >> | 39 | 2008 | R | 85 | 50 | 0 | 1 | 6 | 4.35 | .304 | 1.31 | 9.4 | 2.6 | 7.7 | 49.2 | 51 | 25 | 24 | 6 | 14 | 42 | 0 | 31 | 4 | 0 | 0 | 0 | 0 | 3.73 |