| SP | Burnes, C.Burnes, Corbin >> | 26 | 2021 | R | 91 | 24 | 24 | 10 | 8 | 4.21 | .304 | 1.28 | 8.4 | 3.2 | 10.3 | 141.0 | 131 | 67 | 66 | 13 | 50 | 162 | 1 | 0 | 0 | 1 | 13 | 4 | 2 | 3.05 |
| SP | Woodruff, B.Woodruff, Brandon >> | 28 | 2021 | R | 88 | 24 | 24 | 9 | 10 | 5.13 | .314 | 1.35 | 9.6 | 2.6 | 10.0 | 140.1 | 149 | 81 | 80 | 27 | 41 | 156 | 1 | 0 | 0 | 1 | 12 | 3 | 1 | 4.22 |
| SP | Peralta, F.Peralta, Freddy # >> | 25 | 2021 | R | 96 | 23 | 23 | 8 | 5 | 2.95 | .260 | 1.04 | 6.3 | 3.1 | 10.1 | 131.0 | 91 | 44 | 43 | 11 | 45 | 147 | 0 | 0 | 0 | 0 | 11 | 2 | 2 | 2.92 |
| SP | Wegman, B.Wegman, Bill >> | 29 | 1991 | R | 46 | 23 | 22 | 9 | 9 | 4.47 | .315 | 1.32 | 9.0 | 2.9 | 5.9 | 143.0 | 143 | 74 | 71 | 19 | 46 | 94 | 0 | 0 | 0 | 0 | 11 | 8 | 3 | 4.55 |
| RP | Richards, T.Richards, Trevor >> | 28 | 2021 | R | 90 | 56 | 0 | 3 | 4 | 5.40 | .354 | 1.65 | 9.8 | 5.0 | 10.0 | 65.0 | 71 | 39 | 39 | 13 | 36 | 72 | 0 | 3 | 7 | 0 | 0 | 0 | 9 | 5.05 |
| RP | Boxberger, B.Boxberger, Brad >> | 33 | 2021 | R | 77 | 38 | 0 | 3 | 1 | 5.36 | .349 | 1.61 | 9.7 | 5.0 | 9.5 | 40.1 | 43 | 24 | 24 | 5 | 22 | 42 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.18 |
| RP | Williams, D.Williams, Devin >> | 26 | 2021 | R | 60 | 24 | 0 | 0 | 1 | 3.68 | .275 | 1.14 | 6.1 | 4.1 | 11.9 | 22.0 | 15 | 9 | 9 | 3 | 10 | 29 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.50 |
| CL | Hader, J.Hader, Josh † >> | 27 | 2021 | L | 100 | 43 | 0 | 1 | 2 | 1.81 | .262 | 0.97 | 3.9 | 5.0 | 10.1 | 49.2 | 21 | 10 | 10 | 1 | 27 | 55 | 0 | 26 | 1 | 0 | 0 | 5 | 3 | 2.98 |
| RP | Fingers, R.Fingers, Rollie >> | 36 | 1982 | R | 63 | 29 | 0 | 2 | 2 | 4.65 | .290 | 1.19 | 8.1 | 2.6 | 5.8 | 31.0 | 28 | 16 | 16 | 2 | 9 | 20 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 3.52 |