| SP | Hudson, D.Hudson, Daniel >> | 25 | 2010 | R | 100 | 22 | 22 | 8 | 10 | 3.65 | .289 | 1.20 | 8.3 | 2.5 | 6.5 | 177.1 | 164 | 76 | 72 | 23 | 49 | 128 | 10 | 0 | 0 | 0 | 13 | 3 | 11 | 4.12 |
| SP | Outman, J.Outman, Josh # >> | 28 | 2009 | L | 95 | 22 | 22 | 9 | 7 | 4.43 | .296 | 1.24 | 8.5 | 2.7 | 6.6 | 148.1 | 140 | 73 | 73 | 21 | 44 | 108 | 2 | 0 | 0 | 1 | 11 | 3 | 0 | 4.34 |
| SP | McCarthy, B.McCarthy, Brandon >> | 29 | 2005 | R | 94 | 21 | 21 | 14 | 3 | 3.35 | .280 | 1.16 | 8.5 | 2.0 | 6.2 | 169.1 | 159 | 68 | 63 | 12 | 37 | 117 | 12 | 0 | 0 | 2 | 14 | 2 | 2 | 3.23 |
| SP | Buehrle, M.Buehrle, Mark >> | 33 | 2001 | L | 89 | 21 | 21 | 11 | 7 | 4.48 | .283 | 1.17 | 8.6 | 2.0 | 6.0 | 148.2 | 141 | 78 | 74 | 33 | 33 | 99 | 10 | 0 | 0 | 1 | 11 | 2 | 2 | 5.27 |
| RP | Cordero, C.Cordero, Chad >> | 30 | 2004 | R | 96 | 33 | 0 | 3 | 1 | 1.40 | .194 | 0.70 | 4.6 | 1.8 | 8.8 | 51.1 | 26 | 8 | 8 | 1 | 10 | 50 | 0 | 3 | 0 | 0 | 0 | 1 | 2 | 1.94 |
| RP | Rodriguez, E.Rodriguez, Eddy >> | 31 | 2004 | R | 92 | 12 | 0 | 4 | 1 | 3.80 | .268 | 1.10 | 6.7 | 3.5 | 5.5 | 23.2 | 17 | 10 | 10 | 3 | 9 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.65 |
| RP | Holland, G.Holland, Greg >> | 26 | 2011 | R | 91 | 9 | 0 | 0 | 1 | 5.25 | .308 | 1.33 | 8.3 | 3.8 | 9.8 | 12.0 | 11 | 7 | 7 | 3 | 5 | 13 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 5.33 |