| SP | Hudson, D.Hudson, Daniel >> | 24 | 2010 | R | 97 | 26 | 26 | 10 | 11 | 3.81 | .301 | 1.27 | 8.3 | 3.2 | 7.4 | 198.1 | 182 | 95 | 84 | 21 | 70 | 162 | 8 | 0 | 0 | 0 | 14 | 4 | 5 | 3.86 |
| SP | McCarthy, B.McCarthy, Brandon >> | 28 | 2005 | R | 95 | 26 | 26 | 12 | 10 | 4.06 | .309 | 1.32 | 9.1 | 2.8 | 6.4 | 192.2 | 195 | 94 | 87 | 19 | 60 | 136 | 5 | 0 | 0 | 1 | 13 | 4 | 3 | 3.87 |
| SP | Outman, J.Outman, Josh # >> | 27 | 2009 | L | 92 | 26 | 26 | 9 | 9 | 4.80 | .293 | 1.22 | 8.0 | 3.1 | 5.9 | 138.2 | 122 | 77 | 74 | 23 | 47 | 90 | 0 | 0 | 0 | 0 | 12 | 3 | 2 | 4.95 |
| SP | Buehrle, M.Buehrle, Mark >> | 32 | 2001 | L | 92 | 25 | 25 | 14 | 10 | 3.57 | .277 | 1.12 | 8.2 | 1.9 | 6.1 | 194.1 | 177 | 85 | 77 | 28 | 40 | 131 | 13 | 0 | 0 | 2 | 13 | 6 | 2 | 4.24 |
| RP | Cordero, C.Cordero, Chad >> | 29 | 2004 | R | 96 | 31 | 0 | 2 | 2 | 3.04 | .272 | 1.10 | 6.7 | 3.3 | 9.2 | 47.1 | 35 | 19 | 16 | 4 | 17 | 48 | 0 | 9 | 2 | 0 | 0 | 1 | 2 | 3.21 |
| RP | Rodriguez, E.Rodriguez, Eddy >> | 30 | 2004 | R | 93 | 11 | 0 | 1 | 3 | 6.75 | .298 | 1.28 | 9.0 | 2.8 | 9.0 | 13.1 | 13 | 10 | 10 | 4 | 4 | 13 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 5.92 |
| RP | Holland, G.Holland, Greg >> | 25 | 2011 | R | 92 | 3 | 0 | 1 | 0 | 0.00 | .167 | 0.60 | 6.0 | 0.0 | 12.0 | 3.1 | 2 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0.33 |
| RP | Pinto, R.Pinto, Renyel >> | 29 | 2007 | L | 89 | 6 | 0 | 0 | 0 | 6.35 | .346 | 1.59 | 12.6 | 3.6 | 7.2 | 5.2 | 7 | 4 | 4 | 1 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.20 |
| SP | Gobble, J.Gobble, Jimmy >> | 30 | 2003 | L | 85 | 11 | 0 | 1 | 2 | 3.50 | .280 | 1.12 | 7.5 | 2.7 | 6.0 | 64.1 | 53 | 25 | 25 | 8 | 19 | 43 | 0 | 0 | 0 | 0 | 0 | 3 | 1 | 4.31 |