| SP | Peavy, J.Peavy, Jake # >> | 30 | 2005 | R | 98 | 26 | 26 | 11 | 10 | 4.42 | .316 | 1.39 | 10.0 | 2.5 | 7.6 | 175.0 | 194 | 91 | 86 | 25 | 49 | 148 | 4 | 0 | 0 | 1 | 12 | 0 | 3 | 4.01 |
| SP | Sowers, J.Sowers, Jeremy # >> | 28 | 2006 | L | 87 | 26 | 26 | 13 | 6 | 4.35 | .294 | 1.17 | 7.7 | 2.9 | 5.2 | 178.0 | 152 | 87 | 86 | 21 | 57 | 103 | 3 | 0 | 0 | 1 | 14 | 13 | 2 | 4.56 |
| RP | Delcarmen, M.Delcarmen, Manny >> | 29 | 2007 | R | 97 | 69 | 0 | 4 | 3 | 3.15 | .286 | 1.16 | 6.2 | 4.3 | 7.5 | 91.1 | 63 | 35 | 32 | 9 | 43 | 76 | 0 | 1 | 3 | 0 | 0 | 4 | 0 | 4.16 |
| RP | Shell, S.Shell, Steven >> | 28 | 2008 | R | 94 | 41 | 0 | 5 | 4 | 2.64 | .298 | 1.26 | 6.8 | 4.5 | 7.9 | 58.0 | 44 | 17 | 17 | 3 | 29 | 51 | 0 | 4 | 2 | 0 | 0 | 1 | 2 | 3.47 |
| RP | Rincon, J.Rincon, Juan >> | 32 | 2004 | R | 91 | 11 | 0 | 2 | 0 | 3.07 | .200 | 0.75 | 5.8 | 1.3 | 9.0 | 14.2 | 9 | 5 | 5 | 1 | 2 | 14 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.36 |
| RP | Carvajal, M.Carvajal, Marcos >> | 27 | 2005 | R | 88 | 8 | 0 | 0 | 0 | 4.82 | .404 | 1.93 | 13.0 | 5.0 | 6.0 | 9.1 | 13 | 5 | 5 | 1 | 5 | 6 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 5.11 |
| RP | Feldman, S.Feldman, Scott >> | 28 | 2006 | R | 90 | 10 | 0 | 0 | 0 | 2.45 | .250 | 1.00 | 6.5 | 2.5 | 6.5 | 22.0 | 16 | 6 | 6 | 5 | 6 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.32 |
| CL | Papelbon, J.Papelbon, Jonathan >> | 31 | 2007 | R | 100 | 54 | 0 | 3 | 8 | 3.12 | .297 | 1.25 | 6.6 | 4.7 | 10.7 | 57.2 | 42 | 20 | 20 | 4 | 30 | 68 | 0 | 33 | 6 | 0 | 0 | 1 | 0 | 3.16 |
| SP | Kazmir, S.Kazmir, Scott >> | 27 | 2006 | L | 92 | 7 | 7 | 3 | 2 | 3.45 | .277 | 1.11 | 7.1 | 2.9 | 10.0 | 47.0 | 37 | 18 | 18 | 6 | 15 | 52 | 1 | 0 | 0 | 0 | 5 | 2 | 1 | 3.53 |