| SP | Richards, G.Richards, Garrett >> | 28 | 2014 | R | 97 | 33 | 33 | 12 | 18 | 4.53 | .300 | 1.26 | 9.0 | 2.4 | 7.5 | 222.2 | 222 | 115 | 112 | 33 | 59 | 185 | 6 | 0 | 0 | 1 | 17 | 5 | 25 | 4.13 |
| SP | Buchholz, C.Buchholz, Clay >> | 32 | 2013 | R | 85 | 33 | 33 | 9 | 15 | 4.50 | .316 | 1.37 | 7.4 | 4.9 | 6.3 | 224.0 | 184 | 112 | 112 | 30 | 122 | 157 | 2 | 0 | 0 | 0 | 14 | 4 | 3 | 5.03 |
| SP | Kazmir, S.Kazmir, Scott >> | 32 | 2006 | L | 91 | 32 | 32 | 9 | 16 | 4.14 | .296 | 1.23 | 8.4 | 2.7 | 9.3 | 226.1 | 211 | 108 | 104 | 39 | 67 | 233 | 4 | 0 | 0 | 0 | 17 | 8 | 7 | 4.18 |
| SP | Peavy, J.Peavy, Jake # >> | 35 | 2005 | R | 91 | 32 | 32 | 7 | 14 | 5.35 | .315 | 1.37 | 9.8 | 2.5 | 6.9 | 212.0 | 230 | 128 | 126 | 46 | 60 | 163 | 6 | 0 | 0 | 0 | 13 | 2 | 1 | 5.16 |
| SP | Paxton, J.Paxton, James # >> | 27 | 2014 | L | 85 | 32 | 32 | 11 | 12 | 4.28 | .285 | 1.18 | 8.1 | 2.6 | 6.5 | 206.0 | 185 | 103 | 98 | 27 | 59 | 149 | 1 | 0 | 0 | 0 | 17 | 2 | 17 | 4.15 |
| RP | Miller, A.Miller, Andrew >> | 31 | 2016 | L | 99 | 87 | 0 | 4 | 2 | 3.01 | .238 | 0.92 | 6.2 | 2.2 | 10.4 | 86.2 | 59 | 29 | 29 | 15 | 21 | 99 | 0 | 3 | 3 | 0 | 0 | 1 | 0 | 3.73 |
| RP | Delcarmen, M.Delcarmen, Manny >> | 34 | 2007 | R | 89 | 67 | 0 | 3 | 2 | 2.84 | .234 | 0.89 | 5.2 | 2.9 | 6.5 | 66.2 | 38 | 21 | 21 | 4 | 21 | 48 | 0 | 5 | 1 | 0 | 0 | 2 | 0 | 3.38 |
| RP | Rasmus, C.Rasmus, Cory >> | 28 | 2014 | R | 87 | 32 | 0 | 5 | 4 | 3.78 | .239 | 0.92 | 5.9 | 2.5 | 7.7 | 47.2 | 31 | 20 | 20 | 8 | 13 | 40 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 4.40 |
| RP | Tazawa, J.Tazawa, Junichi >> | 30 | 2012 | R | 87 | 13 | 0 | 0 | 2 | 2.03 | .216 | 0.75 | 6.2 | 0.7 | 9.7 | 13.1 | 9 | 3 | 3 | 1 | 1 | 14 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2.31 |
| RP | Kahnle, T.Kahnle, Tommy >> | 26 | 2014 | R | 85 | 11 | 0 | 0 | 0 | 1.15 | .242 | 0.89 | 5.4 | 3.0 | 9.0 | 15.2 | 9 | 2 | 2 | 2 | 5 | 15 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 3.93 |
| RP | Shell, S.Shell, Steven >> | 33 | 2008 | R | 82 | 13 | 0 | 1 | 1 | 4.30 | .241 | 0.89 | 5.1 | 3.2 | 6.4 | 14.2 | 8 | 7 | 7 | 3 | 5 | 10 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 5.64 |