| SP | Kazmir, S.Kazmir, Scott # >> | 28 | 2006 | L | 94 | 22 | 22 | 9 | 9 | 4.73 | .295 | 1.25 | 8.7 | 2.5 | 9.1 | 156.0 | 151 | 88 | 82 | 32 | 44 | 157 | 4 | 0 | 0 | 1 | 9 | 1 | 2 | 4.52 |
| SP | Sowers, J.Sowers, Jeremy >> | 29 | 2006 | L | 88 | 22 | 22 | 9 | 6 | 4.40 | .298 | 1.26 | 8.8 | 2.6 | 5.2 | 157.2 | 153 | 80 | 77 | 25 | 46 | 91 | 5 | 0 | 0 | 1 | 9 | 2 | 1 | 4.83 |
| RP | Delcarmen, M.Delcarmen, Manny >> | 30 | 2007 | R | 96 | 53 | 0 | 2 | 2 | 3.02 | .278 | 1.14 | 7.0 | 3.4 | 7.8 | 59.2 | 46 | 21 | 20 | 6 | 22 | 51 | 0 | 3 | 3 | 0 | 0 | 1 | 0 | 3.76 |
| RP | Shell, S.Shell, Steven >> | 29 | 2008 | R | 93 | 29 | 0 | 3 | 2 | 2.77 | .255 | 1.03 | 6.2 | 3.0 | 7.2 | 39.0 | 27 | 12 | 12 | 1 | 13 | 31 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 2.74 |
| RP | Carvajal, M.Carvajal, Marcos >> | 28 | 2005 | R | 89 | 11 | 0 | 1 | 1 | 0.63 | .189 | 0.70 | 3.9 | 2.6 | 5.1 | 14.1 | 6 | 1 | 1 | 1 | 4 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.64 |
| RP | Feldman, S.Feldman, Scott >> | 29 | 2006 | R | 88 | 7 | 0 | 1 | 1 | 4.50 | .250 | 1.00 | 7.5 | 1.5 | 7.5 | 6.0 | 5 | 3 | 3 | 1 | 1 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.00 |
| RP | Axford, J.Axford, John >> | 29 | 2010 | R | 84 | 7 | 0 | 0 | 0 | 3.60 | .286 | 1.20 | 7.2 | 3.6 | 10.8 | 10.0 | 8 | 4 | 4 | 2 | 4 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.40 |
| CL | Papelbon, J.Papelbon, Jonathan >> | 32 | 2007 | R | 99 | 44 | 0 | 1 | 7 | 3.91 | .286 | 1.20 | 7.3 | 3.6 | 8.6 | 48.1 | 39 | 21 | 21 | 3 | 19 | 46 | 0 | 26 | 2 | 0 | 0 | 0 | 0 | 3.08 |
| SP | Buchholz, C.Buchholz, Clay >> | 28 | 2010 | R | 82 | 16 | 0 | 3 | 1 | 3.27 | .283 | 1.17 | 7.4 | 3.2 | 5.3 | 77.0 | 63 | 28 | 28 | 7 | 27 | 45 | 0 | 0 | 0 | 0 | 0 | 1 | 5 | 4.10 |