| SP | Scherzer, M.Scherzer, Max >> | 34 | 2018 | R | 98 | 33 | 33 | 15 | 10 | 3.01 | .276 | 1.12 | 7.2 | 2.9 | 11.1 | 218.1 | 175 | 74 | 73 | 17 | 70 | 269 | 4 | 0 | 0 | 2 | 0 | 5 | 3 | 2.58 |
| SP | Hellickson, J.Hellickson, Jeremy >> | 31 | 2018 | R | 77 | 33 | 33 | 12 | 9 | 4.51 | .322 | 1.40 | 9.4 | 3.3 | 8.2 | 159.2 | 166 | 82 | 80 | 24 | 58 | 144 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 4.30 |
| SP | Strasburg, S.Strasburg, Stephen >> | 29 | 2018 | R | 72 | 33 | 33 | 17 | 8 | 2.77 | .280 | 1.14 | 7.3 | 2.9 | 10.8 | 204.1 | 166 | 63 | 63 | 15 | 66 | 244 | 0 | 0 | 0 | 0 | 0 | 6 | 3 | 2.62 |
| SP | Roark, T.Roark, Tanner >> | 31 | 2018 | R | 47 | 32 | 32 | 11 | 11 | 4.69 | .327 | 1.42 | 10.1 | 2.7 | 8.1 | 180.1 | 202 | 94 | 94 | 28 | 54 | 162 | 1 | 0 | 0 | 1 | 0 | 7 | 4 | 4.24 |
| SP | Rodriguez, J.Rodriguez, Jefry >> | 24 | 2018 | R | 40 | 32 | 31 | 8 | 2 | 3.08 | .299 | 1.27 | 6.6 | 4.9 | 8.0 | 134.1 | 98 | 46 | 46 | 13 | 73 | 119 | 0 | 0 | 0 | 0 | 0 | 1 | 5 | 4.14 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 106 | 0 | 4 | 0 | 2.10 | .241 | 0.92 | 6.4 | 1.9 | 10.1 | 94.1 | 67 | 22 | 22 | 5 | 20 | 106 | 0 | 3 | 0 | 0 | 0 | 3 | 4 | 2.17 |
| RP | Miller, J.Miller, Justin >> | 31 | 2018 | R | 74 | 91 | 0 | 11 | 4 | 1.77 | .219 | 0.79 | 5.5 | 1.7 | 10.5 | 107.0 | 65 | 23 | 21 | 5 | 20 | 125 | 0 | 3 | 3 | 0 | 0 | 5 | 1 | 1.97 |
| RP | Suero, W.Suero, Wander >> | 26 | 2018 | R | 57 | 96 | 0 | 5 | 7 | 2.80 | .252 | 0.98 | 6.5 | 2.4 | 10.6 | 103.0 | 74 | 32 | 32 | 10 | 27 | 121 | 0 | 7 | 2 | 0 | 0 | 3 | 4 | 2.79 |
| RP | Herrera, K.Herrera, Kelvin >> | 28 | 2018 | R | 52 | 78 | 0 | 7 | 4 | 2.79 | .261 | 1.06 | 7.6 | 1.9 | 8.0 | 84.0 | 71 | 28 | 26 | 11 | 18 | 75 | 0 | 9 | 3 | 0 | 0 | 0 | 0 | 3.56 |
| RP | Holland, G.Holland, Greg >> | 32 | 2018 | R | 29 | 59 | 0 | 4 | 2 | 2.93 | .317 | 1.37 | 8.5 | 3.9 | 11.6 | 55.1 | 52 | 21 | 18 | 3 | 24 | 71 | 0 | 8 | 3 | 0 | 0 | 1 | 0 | 2.49 |
| RP | Madson, R.Madson, Ryan >> | 38 | 2018 | R | 29 | 49 | 0 | 2 | 1 | 4.41 | .298 | 1.22 | 8.5 | 2.5 | 8.6 | 51.0 | 48 | 25 | 25 | 5 | 14 | 49 | 0 | 5 | 2 | 0 | 0 | 3 | 3 | 3.35 |