| SP | Woodruff, B.Woodruff, Brandon >> | 28 | 2021 | R | 96 | 37 | 37 | 13 | 7 | 3.51 | .302 | 1.27 | 8.5 | 3.0 | 10.2 | 223.1 | 210 | 96 | 87 | 24 | 74 | 252 | 0 | 0 | 0 | 0 | 24 | 6 | 4 | 3.22 |
| SP | Gausman, K.Gausman, Kevin >> | 30 | 2021 | R | 94 | 36 | 36 | 13 | 15 | 4.67 | .329 | 1.44 | 8.5 | 4.5 | 10.2 | 208.1 | 196 | 111 | 108 | 24 | 103 | 235 | 1 | 0 | 0 | 0 | 14 | 7 | 7 | 3.83 |
| SP | Peralta, F.Peralta, Freddy >> | 25 | 2021 | R | 98 | 36 | 36 | 16 | 11 | 3.23 | .295 | 1.21 | 7.0 | 3.9 | 11.5 | 200.1 | 156 | 78 | 72 | 21 | 87 | 255 | 0 | 0 | 0 | 0 | 16 | 8 | 4 | 3.24 |
| SP | McCullers, L.McCullers, Lance >> | 28 | 2021 | R | 79 | 34 | 34 | 13 | 8 | 3.99 | .317 | 1.35 | 7.7 | 4.4 | 10.3 | 194.0 | 167 | 90 | 86 | 20 | 95 | 223 | 1 | 0 | 0 | 1 | 12 | 8 | 11 | 3.63 |
| SP | Quantrill, C.Quantrill, Cal >> | 26 | 2021 | R | 71 | 23 | 23 | 2 | 5 | 5.19 | .364 | 1.65 | 9.8 | 5.1 | 6.1 | 86.2 | 94 | 52 | 50 | 12 | 49 | 58 | 0 | 0 | 0 | 0 | 0 | 6 | 2 | 5.38 |
| CL | Kimbrel, C.Kimbrel, Craig >> | 33 | 2021 | R | 100 | 64 | 0 | 1 | 3 | 2.73 | .305 | 1.28 | 6.9 | 4.7 | 13.7 | 59.1 | 45 | 18 | 18 | 3 | 31 | 90 | 0 | 37 | 4 | 0 | 0 | 2 | 5 | 2.29 |
| SU | Bickford, P.Bickford, Phil >> | 25 | 2021 | R | 91 | 76 | 0 | 7 | 4 | 2.77 | .276 | 1.13 | 6.9 | 3.3 | 11.6 | 91.0 | 70 | 28 | 28 | 11 | 33 | 117 | 0 | 4 | 7 | 0 | 0 | 1 | 0 | 3.12 |
| RP | Treinen, B.Treinen, Blake >> | 33 | 2021 | R | 95 | 89 | 0 | 8 | 7 | 3.19 | .283 | 1.13 | 6.1 | 4.1 | 10.4 | 121.1 | 82 | 45 | 43 | 8 | 55 | 140 | 0 | 1 | 2 | 0 | 0 | 7 | 7 | 3.08 |
| RP | Chafin, A.Chafin, Andrew >> | 31 | 2021 | L | 92 | 85 | 0 | 12 | 6 | 2.71 | .314 | 1.34 | 7.8 | 4.2 | 7.4 | 106.1 | 92 | 35 | 32 | 10 | 50 | 87 | 0 | 1 | 2 | 0 | 0 | 4 | 4 | 4.11 |
| RP | Trivino, L.Trivino, Lou >> | 29 | 2021 | R | 59 | 64 | 0 | 2 | 6 | 4.19 | .297 | 1.24 | 7.9 | 3.3 | 7.5 | 77.1 | 68 | 43 | 36 | 5 | 28 | 64 | 0 | 1 | 4 | 0 | 0 | 2 | 4 | 3.35 |
| SP | Gilbert, T.Gilbert, Tyler >> | 27 | 2021 | L | 88 | 27 | 9 | 2 | 4 | 3.11 | .314 | 1.32 | 7.4 | 4.4 | 6.1 | 81.0 | 67 | 28 | 28 | 8 | 40 | 55 | 0 | 1 | 2 | 0 | 2 | 4 | 0 | 4.56 |