| SP | Scherzer, M.Scherzer, Max >> | 37 | 2021 | R | 100 | 33 | 33 | 11 | 15 | 3.21 | .296 | 1.23 | 7.9 | 3.2 | 10.5 | 215.2 | 189 | 80 | 77 | 25 | 76 | 252 | 0 | 0 | 0 | 0 | 20 | 7 | 4 | 3.33 |
| SP | Houck, T.Houck, Tanner >> | 25 | 2021 | R | 86 | 32 | 32 | 1 | 12 | 4.96 | .349 | 1.54 | 8.8 | 5.1 | 10.6 | 121.2 | 118 | 79 | 67 | 22 | 69 | 143 | 0 | 0 | 0 | 0 | 0 | 9 | 6 | 4.93 |
| SP | Rogers, T.Rogers, Trevor >> | 23 | 2021 | L | 85 | 32 | 32 | 7 | 13 | 5.68 | .354 | 1.59 | 9.6 | 4.7 | 9.9 | 168.0 | 179 | 110 | 106 | 17 | 88 | 185 | 0 | 0 | 0 | 0 | 9 | 9 | 4 | 3.85 |
| RP | Richards, T.Richards, Trevor >> | 28 | 2021 | R | 98 | 88 | 0 | 7 | 2 | 3.27 | .322 | 1.39 | 8.4 | 4.1 | 10.3 | 129.1 | 121 | 48 | 47 | 10 | 59 | 147 | 0 | 4 | 4 | 0 | 0 | 4 | 4 | 3.19 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 29 | 2021 | R | 98 | 81 | 0 | 7 | 5 | 3.61 | .277 | 1.11 | 6.9 | 3.2 | 10.7 | 114.2 | 87 | 50 | 46 | 10 | 40 | 136 | 0 | 4 | 6 | 0 | 0 | 5 | 2 | 2.94 |
| RP | Knebel, C.Knebel, Corey >> | 29 | 2021 | R | 94 | 74 | 0 | 8 | 2 | 3.76 | .295 | 1.22 | 7.9 | 3.1 | 9.9 | 93.1 | 82 | 41 | 39 | 10 | 32 | 102 | 0 | 6 | 3 | 0 | 0 | 3 | 0 | 3.33 |
| RP | Castillo, D.Castillo, Diego >> | 27 | 2021 | R | 94 | 65 | 0 | 7 | 5 | 2.36 | .255 | 0.98 | 6.2 | 2.7 | 11.2 | 87.2 | 60 | 25 | 23 | 4 | 26 | 108 | 0 | 4 | 0 | 0 | 0 | 4 | 0 | 2.15 |
| RP | Suarez, R.Suarez, Ranger >> | 25 | 2021 | L | 89 | 53 | 0 | 9 | 4 | 2.89 | .292 | 1.20 | 7.1 | 3.7 | 9.6 | 87.1 | 69 | 29 | 28 | 15 | 36 | 93 | 0 | 12 | 4 | 0 | 0 | 3 | 0 | 4.45 |
| SP | Stroman, M.Stroman, Marcus >> | 30 | 2021 | R | 72 | 32 | 32 | 7 | 14 | 4.95 | .329 | 1.43 | 9.3 | 3.7 | 8.7 | 172.2 | 177 | 103 | 95 | 24 | 70 | 166 | 0 | 0 | 0 | 0 | 11 | 7 | 1 | 4.23 |
| RP | Colome, A.Colome, Alex >> | 32 | 2021 | R | 32 | 37 | 0 | 0 | 1 | 5.05 | .324 | 1.41 | 8.8 | 4.0 | 7.5 | 41.0 | 40 | 25 | 23 | 8 | 18 | 34 | 0 | 3 | 0 | 0 | 0 | 1 | 2 | 5.27 |