| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 34 | 34 | 14 | 12 | 3.03 | .254 | 0.99 | 6.7 | 2.2 | 11.5 | 240.1 | 179 | 88 | 81 | 28 | 58 | 306 | 1 | 0 | 0 | 0 | 23 | 9 | 0 | 2.80 |
| SP | Ohtani, S.Ohtani, Shohei >> | 26 | 2021 | R | 92 | 34 | 34 | 12 | 12 | 4.23 | .320 | 1.39 | 8.3 | 4.2 | 10.8 | 195.2 | 179 | 101 | 92 | 26 | 92 | 234 | 0 | 0 | 0 | 0 | 14 | 5 | 6 | 3.83 |
| SP | Darvish, Y.Darvish, Yu >> | 34 | 2021 | R | 86 | 33 | 33 | 5 | 17 | 5.25 | .347 | 1.55 | 10.0 | 4.0 | 9.7 | 178.1 | 198 | 119 | 104 | 31 | 79 | 191 | 0 | 0 | 0 | 0 | 9 | 7 | 6 | 4.57 |
| SP | McKenzie, T.McKenzie, Triston >> | 23 | 2021 | R | 85 | 32 | 32 | 9 | 9 | 4.12 | .341 | 1.53 | 8.4 | 5.4 | 9.9 | 159.1 | 148 | 79 | 73 | 20 | 95 | 175 | 0 | 0 | 0 | 0 | 4 | 4 | 3 | 4.30 |
| RP | Antone, T.Antone, Tejay >> | 27 | 2021 | R | 99 | 82 | 0 | 10 | 2 | 3.23 | .306 | 1.30 | 7.5 | 4.3 | 10.9 | 119.2 | 99 | 44 | 43 | 11 | 57 | 144 | 0 | 3 | 5 | 0 | 0 | 2 | 4 | 3.27 |
| SU | Romano, J.Romano, Jordan >> | 28 | 2021 | R | 93 | 59 | 0 | 1 | 4 | 3.71 | .315 | 1.38 | 7.4 | 5.0 | 10.1 | 63.0 | 52 | 31 | 26 | 3 | 35 | 71 | 0 | 3 | 5 | 0 | 0 | 0 | 1 | 3.03 |
| RP | Bednar, D.Bednar, David >> | 26 | 2021 | R | 94 | 80 | 0 | 8 | 5 | 3.00 | .273 | 1.09 | 6.7 | 3.1 | 11.2 | 93.0 | 69 | 38 | 31 | 16 | 32 | 116 | 0 | 3 | 2 | 0 | 0 | 4 | 1 | 3.90 |
| RP | Whitley, K.Whitley, Kodi >> | 26 | 2021 | R | 90 | 65 | 0 | 3 | 3 | 4.35 | .305 | 1.24 | 7.8 | 3.4 | 7.8 | 68.1 | 59 | 33 | 33 | 12 | 26 | 59 | 0 | 1 | 4 | 0 | 0 | 5 | 1 | 4.93 |
| RP | Garcia, Y.Garcia, Yimi >> | 30 | 2021 | R | 67 | 38 | 0 | 3 | 0 | 4.20 | .327 | 1.44 | 9.6 | 3.5 | 9.9 | 49.1 | 52 | 25 | 23 | 7 | 19 | 54 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 3.88 |