| SP | Buehler, W.Buehler, Walker >> | 26 | 2021 | R | 96 | 33 | 33 | 12 | 12 | 3.53 | .303 | 1.26 | 8.3 | 3.0 | 9.7 | 222.0 | 204 | 91 | 87 | 16 | 75 | 239 | 3 | 0 | 0 | 1 | 18 | 10 | 10 | 2.93 |
| SP | Bassitt, C.Bassitt, Chris >> | 32 | 2021 | R | 88 | 32 | 32 | 15 | 11 | 3.56 | .315 | 1.37 | 9.6 | 2.7 | 9.6 | 194.2 | 208 | 80 | 77 | 15 | 58 | 208 | 0 | 0 | 0 | 0 | 16 | 2 | 6 | 2.79 |
| RP | Ramirez, N.Ramirez, Noe >> | 31 | 2021 | R | 96 | 89 | 0 | 4 | 3 | 3.38 | .282 | 1.14 | 6.3 | 3.9 | 8.1 | 114.1 | 80 | 44 | 43 | 13 | 50 | 102 | 0 | 8 | 2 | 0 | 0 | 5 | 5 | 4.14 |
| RP | Sewald, P.Sewald, Paul >> | 31 | 2021 | R | 96 | 80 | 0 | 5 | 3 | 3.58 | .269 | 1.08 | 6.9 | 2.8 | 11.0 | 98.0 | 75 | 44 | 39 | 7 | 31 | 120 | 0 | 9 | 4 | 0 | 0 | 2 | 1 | 2.49 |
| RP | Doval, C.Doval, Camilo >> | 23 | 2021 | R | 92 | 56 | 0 | 3 | 4 | 2.35 | .293 | 1.25 | 7.2 | 4.0 | 9.4 | 65.0 | 52 | 18 | 17 | 3 | 29 | 68 | 0 | 6 | 4 | 0 | 0 | 0 | 4 | 2.85 |
| RP | Pressly, R.Pressly, Ryan >> | 32 | 2021 | R | 91 | 40 | 0 | 3 | 3 | 3.77 | .283 | 1.19 | 7.7 | 2.9 | 9.2 | 43.0 | 37 | 21 | 18 | 6 | 14 | 44 | 0 | 5 | 1 | 0 | 0 | 0 | 2 | 3.74 |