| SP | Glasnow, T.Glasnow, Tyler >> | 27 | 2021 | R | 100 | 33 | 33 | 9 | 21 | 4.46 | .303 | 1.29 | 7.6 | 4.1 | 11.0 | 207.2 | 174 | 108 | 103 | 27 | 94 | 253 | 2 | 0 | 0 | 2 | 16 | 3 | 16 | 3.66 |
| SP | Wheeler, Z.Wheeler, Zack >> | 31 | 2021 | R | 94 | 33 | 33 | 11 | 14 | 4.03 | .294 | 1.22 | 7.7 | 3.3 | 9.9 | 218.2 | 186 | 101 | 98 | 33 | 80 | 239 | 4 | 0 | 0 | 2 | 20 | 7 | 4 | 3.97 |
| SP | Turnbull, S.Turnbull, Spencer >> | 28 | 2021 | R | 92 | 32 | 32 | 13 | 9 | 3.80 | .317 | 1.38 | 8.8 | 3.7 | 8.1 | 194.1 | 189 | 82 | 82 | 22 | 79 | 175 | 0 | 0 | 0 | 0 | 17 | 3 | 0 | 3.94 |
| SP | Giolito, L.Giolito, Lucas >> | 26 | 2021 | R | 86 | 32 | 32 | 13 | 12 | 5.02 | .332 | 1.46 | 9.3 | 3.9 | 10.1 | 181.0 | 187 | 104 | 101 | 28 | 78 | 204 | 0 | 0 | 0 | 0 | 10 | 5 | 12 | 4.13 |
| SP | Wainwright, A.Wainwright, Adam >> | 40 | 2021 | R | 84 | 32 | 32 | 12 | 16 | 4.37 | .316 | 1.32 | 9.2 | 2.7 | 7.3 | 212.1 | 216 | 105 | 103 | 22 | 64 | 172 | 2 | 0 | 0 | 2 | 18 | 14 | 1 | 3.83 |
| RP | Nelson, J.Nelson, Jimmy >> | 32 | 2021 | R | 99 | 85 | 0 | 2 | 5 | 3.14 | .294 | 1.20 | 6.0 | 4.8 | 11.3 | 109.0 | 73 | 38 | 38 | 10 | 58 | 137 | 0 | 7 | 2 | 0 | 0 | 5 | 7 | 3.41 |
| RP | Iglesias, R.Iglesias, Raisel >> | 31 | 2021 | R | 94 | 64 | 0 | 4 | 6 | 3.09 | .244 | 0.96 | 6.7 | 2.0 | 9.2 | 81.2 | 60 | 29 | 28 | 11 | 18 | 83 | 0 | 8 | 4 | 0 | 0 | 1 | 0 | 3.42 |
| RP | Garcia, J.Garcia, Jarlin >> | 28 | 2021 | L | 90 | 30 | 0 | 1 | 0 | 3.41 | .346 | 1.59 | 9.6 | 4.7 | 12.7 | 29.0 | 31 | 11 | 11 | 3 | 15 | 41 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 3.07 |
| RP | Barnes, M.Barnes, Matt >> | 31 | 2021 | R | 83 | 27 | 0 | 1 | 0 | 2.79 | .250 | 1.00 | 8.1 | 0.9 | 8.4 | 29.0 | 26 | 9 | 9 | 4 | 3 | 27 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 3.24 |