| SP | Santana, J.Santana, Johan # >> | 32 | 2004 | L | 100 | 28 | 28 | 12 | 8 | 3.83 | .282 | 1.14 | 7.3 | 3.0 | 8.5 | 197.1 | 159 | 88 | 84 | 24 | 65 | 187 | 6 | 0 | 0 | 1 | 18 | 8 | 7 | 3.80 |
| SP | Buchholz, T.Buchholz, Taylor >> | 24 | 2006 | R | 86 | 28 | 28 | 7 | 7 | 4.56 | .290 | 1.20 | 8.5 | 2.3 | 6.8 | 165.2 | 155 | 86 | 84 | 25 | 43 | 124 | 0 | 0 | 0 | 0 | 14 | 5 | 8 | 4.34 |
| SP | Billingsley, C.Billingsley, Chad >> | 23 | 2007 | R | 68 | 27 | 27 | 9 | 7 | 4.38 | .322 | 1.40 | 8.0 | 4.7 | 5.1 | 139.2 | 123 | 69 | 68 | 23 | 72 | 78 | 0 | 0 | 0 | 0 | 7 | 4 | 2 | 5.67 |
| SP | Francis, J.Francis, Jeff † >> | 25 | 2006 | L | 78 | 26 | 26 | 14 | 6 | 3.65 | .301 | 1.27 | 8.5 | 2.9 | 5.9 | 180.0 | 170 | 75 | 73 | 23 | 58 | 117 | 0 | 0 | 0 | 0 | 17 | 4 | 0 | 4.39 |
| SP | Owings, M.Owings, Micah # >> | 22 | 2007 | R | 36 | 25 | 23 | 11 | 6 | 4.81 | .317 | 1.35 | 9.5 | 2.7 | 6.4 | 119.2 | 125 | 69 | 64 | 16 | 36 | 85 | 0 | 0 | 0 | 0 | 11 | 6 | 4 | 4.38 |
| CL | Gonzalez, M.Gonzalez, Mike >> | 28 | 2004 | L | 79 | 64 | 0 | 1 | 1 | 3.75 | .283 | 1.18 | 8.3 | 2.4 | 10.1 | 60.0 | 55 | 26 | 25 | 3 | 16 | 67 | 0 | 38 | 9 | 0 | 0 | 0 | 3 | 2.22 |
| RP | Sherrill, G.Sherrill, George >> | 22 | 2007 | L | 67 | 72 | 0 | 11 | 4 | 3.02 | .268 | 1.06 | 7.0 | 2.6 | 9.8 | 89.1 | 69 | 31 | 30 | 12 | 26 | 97 | 0 | 1 | 0 | 0 | 0 | 3 | 3 | 3.55 |
| RP | Marmol, C.Marmol, Carlos >> | 23 | 2007 | R | 73 | 41 | 0 | 4 | 3 | 2.91 | .292 | 1.22 | 6.1 | 5.1 | 10.0 | 55.2 | 37 | 18 | 18 | 6 | 31 | 61 | 0 | 0 | 3 | 0 | 0 | 1 | 2 | 3.95 |
| RP | Fuentes, B.Fuentes, Brian >> | 27 | 2005 | L | 59 | 47 | 0 | 3 | 4 | 3.63 | .293 | 1.23 | 8.9 | 2.2 | 9.3 | 62.0 | 61 | 27 | 25 | 9 | 15 | 64 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 3.60 |