| SP | Weaver, J.Weaver, Jered >> | 25 | 2006 | R | 99 | 28 | 28 | 14 | 9 | 4.03 | .286 | 1.15 | 7.9 | 2.5 | 6.5 | 209.2 | 183 | 96 | 94 | 32 | 58 | 152 | 9 | 0 | 0 | 0 | 15 | 11 | 4 | 4.53 |
| SP | Wainwright, A.Wainwright, Adam † >> | 24 | 2010 | R | 95 | 28 | 28 | 14 | 11 | 3.92 | .291 | 1.22 | 8.4 | 2.6 | 7.0 | 208.2 | 195 | 94 | 91 | 25 | 60 | 161 | 6 | 0 | 0 | 1 | 17 | 2 | 2 | 3.91 |
| SP | Hamels, C.Hamels, Cole >> | 25 | 2006 | L | 95 | 26 | 26 | 11 | 11 | 3.96 | .299 | 1.25 | 8.8 | 2.5 | 8.5 | 179.2 | 175 | 84 | 79 | 27 | 49 | 170 | 2 | 0 | 0 | 0 | 14 | 6 | 5 | 3.98 |
| SP | Kazmir, S.Kazmir, Scott >> | 27 | 2005 | L | 43 | 26 | 26 | 8 | 12 | 4.95 | .347 | 1.56 | 8.8 | 5.3 | 7.5 | 161.2 | 158 | 97 | 89 | 21 | 95 | 134 | 1 | 0 | 0 | 0 | 12 | 5 | 5 | 4.89 |
| SP | Santana, E.Santana, Ervin >> | 26 | 2005 | R | 68 | 22 | 21 | 7 | 10 | 5.57 | .346 | 1.55 | 10.4 | 3.5 | 5.1 | 126.0 | 146 | 82 | 78 | 16 | 49 | 71 | 1 | 0 | 0 | 0 | 10 | 5 | 5 | 4.81 |
| RP | Rincon, J.Rincon, Juan >> | 29 | 2004 | R | 62 | 69 | 0 | 5 | 4 | 4.84 | .313 | 1.32 | 8.8 | 3.1 | 9.2 | 89.1 | 87 | 53 | 48 | 16 | 31 | 91 | 0 | 1 | 2 | 0 | 0 | 4 | 2 | 4.47 |
| RP | Donnelly, B.Donnelly, Brendan >> | 30 | 2003 | R | 26 | 49 | 0 | 2 | 2 | 5.80 | .356 | 1.64 | 11.0 | 3.8 | 7.5 | 54.1 | 66 | 39 | 35 | 12 | 23 | 45 | 0 | 1 | 2 | 0 | 0 | 1 | 4 | 5.56 |
| RP | Cordero, C.Cordero, Chad >> | 29 | 2004 | R | 31 | 18 | 0 | 0 | 1 | 2.95 | .297 | 1.27 | 6.9 | 4.7 | 8.6 | 21.1 | 16 | 7 | 7 | 2 | 11 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.90 |
| SP | Pavano, C.Pavano, Carl >> | 31 | 2003 | R | 35 | 6 | 3 | 1 | 2 | 7.65 | .412 | 2.10 | 14.0 | 5.0 | 3.2 | 20.0 | 31 | 17 | 17 | 9 | 11 | 7 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 9.80 |
| RP | Marte, D.Marte, Damaso >> | 32 | 2002 | L | 19 | 19 | 0 | 1 | 1 | 10.13 | .442 | 2.31 | 15.2 | 5.6 | 7.3 | 16.0 | 27 | 18 | 18 | 5 | 10 | 13 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 7.50 |