| SP | Johnson, R.Johnson, Randy † >> | 41 | 2004 | L | 90 | 33 | 33 | 15 | 13 | 3.79 | .304 | 1.28 | 8.8 | 2.8 | 9.9 | 218.1 | 212 | 108 | 92 | 26 | 68 | 240 | 3 | 0 | 0 | 0 | 21 | 6 | 4 | 3.37 |
| SP | Flaherty, J.Flaherty, Jack >> | 23 | 2019 | R | 82 | 32 | 32 | 9 | 13 | 5.24 | .330 | 1.43 | 9.2 | 3.7 | 9.4 | 165.0 | 168 | 112 | 96 | 25 | 68 | 172 | 0 | 0 | 0 | 0 | 13 | 8 | 3 | 4.27 |
| SP | Higuera, T.Higuera, Teddy >> | 30 | 1988 | L | 65 | 32 | 32 | 11 | 17 | 4.75 | .309 | 1.33 | 8.8 | 3.2 | 7.3 | 195.1 | 191 | 115 | 103 | 31 | 69 | 158 | 2 | 0 | 0 | 1 | 15 | 2 | 0 | 4.54 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 85 | 0 | 2 | 4 | 3.27 | .325 | 1.42 | 8.1 | 4.8 | 10.1 | 115.2 | 103 | 50 | 42 | 13 | 61 | 129 | 0 | 6 | 5 | 0 | 0 | 3 | 1 | 3.90 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 91 | 71 | 0 | 6 | 3 | 3.66 | .301 | 1.23 | 7.7 | 3.3 | 10.3 | 86.0 | 74 | 35 | 35 | 12 | 32 | 98 | 0 | 11 | 1 | 0 | 0 | 5 | 0 | 3.83 |
| RP | Nathan, J.Nathan, Joe # >> | 32 | 2006 | R | 86 | 55 | 0 | 4 | 3 | 3.36 | .303 | 1.25 | 8.5 | 2.7 | 9.6 | 59.0 | 56 | 30 | 22 | 6 | 18 | 63 | 0 | 4 | 3 | 0 | 0 | 3 | 1 | 3.25 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 73 | 45 | 0 | 3 | 0 | 4.20 | .299 | 1.24 | 8.3 | 2.9 | 10.5 | 49.1 | 45 | 26 | 23 | 10 | 16 | 57 | 0 | 4 | 2 | 0 | 0 | 2 | 3 | 4.43 |