| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 95 | 19 | 19 | 7 | 6 | 3.94 | .306 | 1.29 | 8.0 | 3.7 | 9.1 | 130.1 | 115 | 59 | 57 | 21 | 53 | 132 | 0 | 0 | 0 | 0 | 13 | 4 | 2 | 4.38 |
| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 18 | 18 | 6 | 4 | 3.54 | .263 | 1.05 | 7.1 | 2.3 | 8.1 | 127.0 | 100 | 50 | 50 | 17 | 33 | 114 | 3 | 0 | 0 | 1 | 12 | 3 | 0 | 3.80 |
| SP | Sutton, D.Sutton, Don † # >> | 27 | 1972 | R | 85 | 18 | 18 | 13 | 3 | 3.76 | .279 | 1.12 | 7.4 | 2.7 | 6.3 | 131.2 | 108 | 56 | 55 | 16 | 40 | 92 | 6 | 0 | 0 | 0 | 10 | 5 | 5 | 4.21 |
| CL | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 84 | 35 | 0 | 1 | 4 | 2.97 | .278 | 1.16 | 8.3 | 2.3 | 11.5 | 36.1 | 33 | 14 | 12 | 7 | 9 | 46 | 0 | 13 | 6 | 0 | 0 | 0 | 1 | 3.72 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 80 | 43 | 0 | 3 | 2 | 3.28 | .259 | 1.03 | 4.9 | 4.5 | 10.6 | 46.2 | 25 | 18 | 17 | 6 | 23 | 54 | 0 | 2 | 0 | 0 | 0 | 1 | 1 | 3.91 |
| SU | Rodney, F.Rodney, Fernando >> | 35 | 2012 | R | 80 | 32 | 0 | 2 | 1 | 3.69 | .286 | 1.17 | 7.8 | 2.9 | 9.0 | 31.2 | 27 | 13 | 13 | 4 | 10 | 31 | 0 | 3 | 4 | 0 | 0 | 1 | 0 | 3.74 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 76 | 29 | 0 | 2 | 1 | 5.46 | .359 | 1.61 | 10.9 | 3.5 | 8.0 | 28.0 | 34 | 17 | 17 | 5 | 11 | 25 | 0 | 2 | 0 | 0 | 0 | 2 | 2 | 4.93 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 72 | 21 | 0 | 2 | 1 | 7.13 | .354 | 1.64 | 10.6 | 4.8 | 10.1 | 17.2 | 20 | 14 | 14 | 5 | 9 | 19 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 6.18 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 64 | 18 | 0 | 0 | 1 | 3.43 | .300 | 1.29 | 7.3 | 4.3 | 6.9 | 21.0 | 17 | 8 | 8 | 2 | 10 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 4.14 |
| SP | Lincecum, T.Lincecum, Tim >> | 25 | 2009 | R | 59 | 5 | 0 | 2 | 1 | 1.88 | .246 | 0.98 | 7.1 | 1.9 | 7.1 | 14.1 | 11 | 3 | 3 | 0 | 3 | 11 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 2.07 |