| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 19 | 19 | 8 | 8 | 3.41 | .279 | 1.13 | 7.6 | 2.6 | 12.0 | 108.1 | 91 | 42 | 41 | 12 | 31 | 144 | 0 | 0 | 0 | 0 | 12 | 4 | 0 | 2.75 |
| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 97 | 18 | 18 | 7 | 7 | 5.17 | .321 | 1.38 | 9.5 | 3.0 | 8.8 | 111.1 | 117 | 64 | 64 | 22 | 37 | 108 | 0 | 0 | 0 | 0 | 8 | 4 | 3 | 4.74 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 91 | 18 | 18 | 4 | 9 | 5.09 | .300 | 1.28 | 8.4 | 3.2 | 9.7 | 111.1 | 104 | 63 | 63 | 19 | 39 | 120 | 0 | 0 | 0 | 0 | 8 | 0 | 1 | 4.12 |
| SP | Higuera, T.Higuera, Teddy >> | 30 | 1988 | L | 65 | 21 | 18 | 8 | 6 | 4.02 | .306 | 1.32 | 8.2 | 3.7 | 6.3 | 125.1 | 114 | 57 | 56 | 12 | 51 | 87 | 4 | 0 | 0 | 2 | 9 | 1 | 0 | 4.10 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 96 | 58 | 0 | 2 | 4 | 4.91 | .325 | 1.44 | 11.0 | 2.0 | 12.2 | 77.0 | 94 | 42 | 42 | 10 | 17 | 104 | 0 | 8 | 4 | 0 | 0 | 0 | 0 | 2.65 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 40 | 0 | 2 | 1 | 1.56 | .228 | 0.88 | 5.5 | 2.4 | 11.1 | 52.0 | 32 | 10 | 9 | 3 | 14 | 64 | 0 | 4 | 0 | 0 | 0 | 0 | 1 | 2.10 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 79 | 34 | 0 | 1 | 2 | 3.96 | .292 | 1.24 | 6.5 | 4.8 | 10.5 | 36.1 | 26 | 16 | 16 | 7 | 19 | 42 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.78 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 76 | 28 | 0 | 2 | 2 | 6.27 | .322 | 1.36 | 10.1 | 2.2 | 9.8 | 33.0 | 37 | 26 | 23 | 7 | 8 | 36 | 0 | 1 | 1 | 0 | 0 | 2 | 2 | 4.48 |