| SP | Santana, J.Santana, Johan >> | 31 | 2004 | L | 100 | 32 | 32 | 14 | 13 | 4.61 | .294 | 1.24 | 8.6 | 2.6 | 7.9 | 236.1 | 225 | 126 | 121 | 35 | 67 | 208 | 5 | 0 | 0 | 1 | 16 | 3 | 4 | 4.06 |
| SP | Hernandez, F.Hernandez, Felix >> | 23 | 2014 | R | 94 | 32 | 32 | 10 | 10 | 5.21 | .322 | 1.41 | 9.2 | 3.5 | 7.7 | 212.2 | 217 | 129 | 123 | 26 | 82 | 182 | 2 | 0 | 0 | 1 | 13 | 4 | 18 | 4.09 |
| SP | Pettitte, A.Pettitte, Andy >> | 30 | 2005 | L | 75 | 32 | 32 | 13 | 15 | 5.11 | .318 | 1.38 | 10.0 | 2.4 | 5.0 | 232.1 | 258 | 141 | 132 | 40 | 63 | 128 | 8 | 0 | 0 | 1 | 11 | 4 | 2 | 5.00 |
| SP | Keuchel, D.Keuchel, Dallas >> | 21 | 2015 | L | 70 | 32 | 32 | 5 | 17 | 6.30 | .352 | 1.60 | 11.0 | 3.4 | 5.3 | 207.0 | 254 | 155 | 145 | 41 | 78 | 123 | 3 | 0 | 0 | 0 | 10 | 6 | 2 | 5.60 |
| SP | Loaiza, E.Loaiza, Esteban >> | 25 | 2003 | R | 65 | 31 | 31 | 14 | 13 | 5.43 | .329 | 1.44 | 10.1 | 2.8 | 5.8 | 212.1 | 239 | 138 | 128 | 29 | 67 | 137 | 4 | 0 | 0 | 1 | 13 | 6 | 7 | 4.52 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 95 | 70 | 0 | 7 | 4 | 4.45 | .292 | 1.21 | 8.3 | 2.6 | 8.4 | 85.0 | 78 | 42 | 42 | 13 | 25 | 79 | 0 | 1 | 2 | 0 | 0 | 2 | 1 | 4.08 |
| RP | Boxberger, B.Boxberger, Brad >> | 21 | 2014 | R | 80 | 7 | 0 | 3 | 0 | 0.00 | .292 | 1.24 | 7.2 | 5.4 | 12.6 | 5.2 | 4 | 1 | 0 | 1 | 3 | 7 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.60 |
| CL | Holland, G.Holland, Greg >> | 21 | 2013 | R | 70 | 51 | 0 | 3 | 6 | 3.24 | .255 | 1.03 | 6.5 | 2.8 | 7.1 | 58.1 | 42 | 21 | 21 | 1 | 18 | 46 | 0 | 28 | 4 | 0 | 0 | 0 | 0 | 2.57 |
| SP | Fernandez, J.Fernandez, Jose >> | 20 | 2016 | R | 31 | 16 | 1 | 1 | 1 | 6.15 | .347 | 1.58 | 10.6 | 3.7 | 8.1 | 71.2 | 84 | 50 | 49 | 11 | 29 | 64 | 0 | 0 | 0 | 0 | 1 | 1 | 7 | 4.48 |