| SP | Buchholz, C.Buchholz, Clay >> | 24 | 2007 | R | 97 | 6 | 6 | 4 | 1 | 3.05 | .281 | 1.17 | 6.9 | 3.8 | 7.3 | 38.1 | 29 | 13 | 13 | 3 | 16 | 31 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 3.66 |
| SP | Crawford, P.Crawford, Paxton >> | 30 | 2000 | R | 87 | 6 | 6 | 2 | 1 | 5.23 | .340 | 1.55 | 10.7 | 3.2 | 4.6 | 31.0 | 37 | 18 | 18 | 7 | 11 | 16 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 5.97 |
| SP | Gabbard, K.Gabbard, Kason >> | 26 | 2006 | L | 69 | 6 | 6 | 0 | 3 | 4.68 | .348 | 1.44 | 7.9 | 5.0 | 4.3 | 25.0 | 22 | 13 | 13 | 2 | 14 | 12 | 0 | 0 | 0 | 0 | 0 | 4 | 1 | 5.24 |
| SP | Ohka, T.Ohka, Tomokazu >> | 31 | 2000 | R | 84 | 5 | 5 | 3 | 1 | 3.57 | .307 | 1.27 | 8.0 | 3.6 | 5.9 | 35.1 | 31 | 16 | 14 | 4 | 14 | 23 | 0 | 0 | 0 | 0 | 5 | 2 | 3 | 4.54 |
| SU | Delcarmen, M.Delcarmen, Manny >> | 26 | 2007 | R | 85 | 14 | 0 | 0 | 0 | 5.11 | .327 | 1.46 | 8.3 | 5.3 | 8.3 | 12.1 | 11 | 7 | 7 | 1 | 7 | 11 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 4.00 |
| RP | Corcoran, T.Corcoran, Tim >> | 29 | 2005 | R | 81 | 14 | 0 | 0 | 1 | 1.69 | .238 | 0.94 | 5.4 | 3.6 | 9.0 | 10.2 | 6 | 2 | 2 | 1 | 4 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.50 |
| RP | DiNardo, L.DiNardo, Lenny >> | 29 | 2005 | L | 81 | 13 | 0 | 0 | 0 | 2.57 | .344 | 1.57 | 10.3 | 3.9 | 5.1 | 7.0 | 8 | 2 | 2 | 0 | 3 | 4 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.14 |
| RP | Beirne, K.Beirne, Kevin >> | 33 | 2000 | R | 69 | 10 | 0 | 1 | 2 | 9.64 | .472 | 2.57 | 13.0 | 11.0 | 9.0 | 9.1 | 13 | 12 | 10 | 3 | 11 | 9 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 9.33 |
| CL | Papelbon, J.Papelbon, Jonathan >> | 28 | 2007 | R | 100 | 13 | 0 | 0 | 3 | 4.11 | .270 | 1.04 | 7.8 | 1.8 | 12.0 | 15.1 | 13 | 7 | 7 | 3 | 3 | 20 | 0 | 8 | 1 | 0 | 0 | 1 | 0 | 3.73 |
| SP | Paniagua, J.Paniagua, Jose >> | 33 | 1996 | R | 62 | 7 | 0 | 2 | 1 | 3.00 | .301 | 1.29 | 9.0 | 2.6 | 5.3 | 24.0 | 24 | 8 | 8 | 2 | 7 | 14 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 3.79 |