| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 10 | 10 | 5 | 3 | 3.91 | .290 | 1.16 | 8.8 | 1.7 | 11.4 | 76.0 | 74 | 33 | 33 | 5 | 14 | 96 | 2 | 0 | 0 | 1 | 6 | 5 | 0 | 2.08 |
| SP | Cameron, N.Cameron, Noah >> | 25 | 2025 | L | 80 | 10 | 10 | 2 | 4 | 4.60 | .313 | 1.27 | 9.0 | 2.6 | 8.7 | 60.2 | 60 | 34 | 31 | 12 | 17 | 58 | 0 | 0 | 0 | 0 | 5 | 6 | 5 | 4.82 |
| SP | Gausman, K.Gausman, Kevin # >> | 34 | 2025 | R | 84 | 9 | 9 | 4 | 3 | 5.24 | .337 | 1.49 | 10.6 | 2.8 | 7.4 | 55.0 | 65 | 32 | 32 | 11 | 17 | 45 | 0 | 0 | 0 | 0 | 4 | 2 | 1 | 5.00 |
| SP | Cabrera, E.Cabrera, Edward >> | 27 | 2025 | R | 69 | 10 | 10 | 3 | 3 | 4.67 | .311 | 1.35 | 9.0 | 3.3 | 8.2 | 44.1 | 44 | 27 | 23 | 7 | 16 | 40 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 4.34 |
| RP | Rodríguez, Y.Rodríguez, Yariel >> | 28 | 2025 | R | 65 | 28 | 0 | 1 | 0 | 2.52 | .248 | 0.99 | 6.2 | 2.8 | 7.8 | 39.1 | 27 | 11 | 11 | 3 | 12 | 34 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 3.18 |
| CL | Santana, D.Santana, Dennis >> | 29 | 2025 | R | 92 | 25 | 0 | 1 | 3 | 4.56 | .297 | 1.27 | 8.2 | 3.5 | 10.2 | 23.2 | 21 | 12 | 12 | 3 | 9 | 26 | 0 | 12 | 2 | 0 | 0 | 0 | 0 | 3.61 |
| RP | Mattson, I.Mattson, Isaac >> | 29 | 2025 | R | 62 | 17 | 0 | 2 | 1 | 7.91 | .370 | 1.71 | 9.9 | 5.7 | 10.4 | 19.1 | 21 | 21 | 17 | 5 | 12 | 22 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 6.16 |
| RP | Coulombe, D.Coulombe, Daniel >> | 35 | 2025 | L | 61 | 20 | 0 | 2 | 0 | 3.66 | .330 | 1.37 | 10.4 | 2.4 | 9.9 | 19.2 | 22 | 8 | 8 | 4 | 5 | 21 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 4.63 |