| SP | Holmes, C.Holmes, Clay NYY >> | 32 | 2025 | R | 49 | 33 | 33 | 11 | 9 | 3.08 | .288 | 1.19 | 7.3 | 3.4 | 6.8 | 175.1 | 142 | 64 | 60 | 21 | 67 | 132 | 0 | 0 | 0 | 0 | 12 | 4 | 3 | 4.27 |
| SP | Chen, B.Chen, Bruce BAL >> | 28 | 2005 | L | 46 | 32 | 32 | 11 | 16 | 4.82 | .325 | 1.43 | 9.6 | 3.3 | 5.9 | 175.2 | 187 | 94 | 94 | 23 | 64 | 115 | 0 | 0 | 0 | 0 | 15 | 3 | 4 | 4.54 |
| SP | Anderson, T.Anderson, Tyler COL >> | 35 | 2025 | L | 25 | 32 | 32 | 6 | 5 | 3.85 | .323 | 1.43 | 8.9 | 4.1 | 5.9 | 126.1 | 124 | 55 | 54 | 20 | 57 | 82 | 0 | 0 | 0 | 0 | 1 | 0 | 2 | 5.12 |
| SP | Freeland, K.Freeland, Kyle COL # >> | 31 | 2024 | L | 19 | 33 | 32 | 6 | 13 | 5.62 | .334 | 1.46 | 10.3 | 2.9 | 7.8 | 125.0 | 143 | 79 | 78 | 25 | 40 | 108 | 0 | 0 | 0 | 0 | 3 | 5 | 1 | 4.95 |
| SP | Koosman, J.Koosman, Jerry NYM >> | 43 | 1985 | L | 18 | 32 | 32 | 4 | 14 | 4.23 | .302 | 1.28 | 8.1 | 3.4 | 5.8 | 134.0 | 120 | 65 | 63 | 18 | 51 | 86 | 0 | 0 | 0 | 0 | 2 | 3 | 4 | 4.67 |
| RP | Betancourt, R.Betancourt, Rafael COL >> | 36 | 2011 | R | 93 | 91 | 0 | 12 | 4 | 1.61 | .240 | 0.94 | 6.3 | 2.1 | 8.1 | 139.2 | 98 | 27 | 25 | 3 | 33 | 125 | 0 | 2 | 0 | 0 | 0 | 1 | 3 | 2.22 |
| RP | Ramirez, R.Ramirez, Ramon COL >> | 29 | 2010 | R | 67 | 93 | 0 | 6 | 3 | 2.79 | .250 | 0.99 | 6.0 | 2.9 | 6.6 | 132.1 | 88 | 41 | 41 | 10 | 43 | 97 | 0 | 2 | 2 | 0 | 0 | 1 | 4 | 3.52 |
| RP | Kahnle, T.Kahnle, Tommy COL >> | 35 | 2025 | R | 48 | 102 | 0 | 3 | 3 | 1.46 | .248 | 0.97 | 5.6 | 3.1 | 5.2 | 123.0 | 76 | 22 | 20 | 3 | 43 | 71 | 0 | 6 | 2 | 0 | 0 | 3 | 4 | 3.28 |
| RP | Martin, C.Martin, Chris BOS >> | 39 | 2025 | R | 46 | 83 | 0 | 5 | 4 | 2.70 | .274 | 1.10 | 8.0 | 2.0 | 11.0 | 86.2 | 76 | 26 | 26 | 6 | 19 | 105 | 0 | 6 | 5 | 0 | 0 | 3 | 4 | 2.23 |
| RP | Myers, M.Myers, Mike COL >> | 37 | 2006 | L | 32 | 119 | 0 | 5 | 2 | 2.63 | .255 | 1.02 | 6.5 | 2.6 | 7.9 | 99.1 | 72 | 36 | 29 | 8 | 29 | 87 | 0 | 8 | 3 | 0 | 0 | 1 | 2 | 3.20 |
| RP | Belisle, M.Belisle, Matt COL >> | 32 | 2012 | R | 24 | 70 | 0 | 7 | 6 | 2.89 | .264 | 1.08 | 8.3 | 1.4 | 7.4 | 87.1 | 80 | 29 | 28 | 6 | 14 | 72 | 0 | 12 | 4 | 0 | 0 | 0 | 2 | 2.72 |
| RP | Reynolds, M.Reynolds, Matt COL >> | 27 | 2012 | L | 20 | 74 | 0 | 5 | 2 | 2.00 | .290 | 1.23 | 7.9 | 3.2 | 8.7 | 67.2 | 59 | 16 | 15 | 2 | 24 | 65 | 0 | 9 | 1 | 0 | 0 | 0 | 3 | 2.52 |