| SP | Kelly, M.Kelly, Merrill AZ >> | 31 | 2020 | R | 90 | 34 | 34 | 11 | 12 | 3.20 | .283 | 1.17 | 8.3 | 2.2 | 6.8 | 210.2 | 194 | 84 | 75 | 12 | 52 | 158 | 1 | 0 | 0 | 1 | 20 | 3 | 0 | 3.02 |
| SP | Gallen, Z.Gallen, Zac AZ >> | 29 | 2025 | R | 54 | 33 | 33 | 9 | 14 | 3.63 | .302 | 1.26 | 8.4 | 3.0 | 7.2 | 178.1 | 166 | 84 | 72 | 18 | 59 | 142 | 1 | 0 | 0 | 1 | 17 | 7 | 1 | 3.83 |
| SP | Benes, A.Benes, Andy AZ # >> | 35 | 2002 | R | 50 | 8 | 8 | 0 | 4 | 5.18 | .396 | 1.91 | 12.3 | 4.9 | 6.5 | 33.0 | 45 | 24 | 19 | 2 | 18 | 24 | 0 | 0 | 0 | 0 | 3 | 2 | 0 | 4.15 |
| SP | Blue, V.Blue, Vida OAK # >> | 37 | 1986 | L | 43 | 33 | 33 | 12 | 14 | 4.46 | .335 | 1.49 | 8.7 | 4.7 | 6.3 | 165.1 | 160 | 94 | 82 | 16 | 87 | 115 | 0 | 0 | 0 | 0 | 13 | 3 | 2 | 4.50 |
| SP | Scherzer, M.Scherzer, Max AZ >> | 41 | 2025 | R | 41 | 33 | 31 | 10 | 6 | 3.34 | .294 | 1.22 | 8.7 | 2.3 | 6.4 | 167.0 | 161 | 74 | 62 | 15 | 43 | 119 | 0 | 0 | 0 | 0 | 10 | 5 | 0 | 3.60 |
| RP | Rodriguez, F.Rodriguez, Felix AZ >> | 29 | 2001 | R | 89 | 106 | 0 | 5 | 2 | 2.96 | .305 | 1.31 | 7.4 | 4.5 | 10.1 | 121.2 | 99 | 41 | 40 | 8 | 60 | 136 | 0 | 6 | 4 | 0 | 0 | 1 | 4 | 3.12 |
| RP | Weaver, L.Weaver, Luke AZ >> | 31 | 2025 | R | 86 | 103 | 0 | 7 | 5 | 2.85 | .300 | 1.24 | 8.0 | 3.3 | 9.6 | 113.2 | 100 | 42 | 36 | 7 | 41 | 121 | 0 | 6 | 2 | 0 | 0 | 5 | 1 | 2.88 |
| RP | Cahill, T.Cahill, Trevor AZ >> | 32 | 2020 | R | 76 | 78 | 0 | 8 | 4 | 2.92 | .316 | 1.37 | 7.4 | 4.9 | 10.5 | 114.0 | 94 | 48 | 37 | 7 | 62 | 133 | 0 | 10 | 2 | 0 | 0 | 2 | 1 | 3.15 |
| RP | Burgmeier, T.Burgmeier, Tom BOS >> | 39 | 1982 | L | 46 | 81 | 0 | 5 | 8 | 4.07 | .299 | 1.28 | 9.0 | 2.5 | 5.9 | 128.1 | 128 | 65 | 58 | 16 | 36 | 84 | 0 | 11 | 2 | 0 | 0 | 0 | 2 | 4.16 |
| RP | Chafin, A.Chafin, Andrew AZ # >> | 35 | 2025 | L | 34 | 109 | 0 | 2 | 3 | 4.35 | .321 | 1.40 | 7.9 | 4.6 | 9.6 | 91.0 | 80 | 45 | 44 | 5 | 47 | 97 | 0 | 3 | 1 | 0 | 0 | 2 | 16 | 3.20 |