| SP | Bumgarner, M.Bumgarner, Madison SF >> | 23 | 2013 | L | 97 | 33 | 33 | 15 | 13 | 3.16 | .288 | 1.20 | 7.3 | 3.5 | 6.3 | 211.0 | 172 | 77 | 74 | 10 | 82 | 147 | 3 | 0 | 0 | 1 | 22 | 2 | 5 | 3.42 |
| SP | Perry, G.Perry, Gaylord SF # >> | 28 | 1966 | R | 70 | 32 | 32 | 12 | 11 | 4.64 | .295 | 1.24 | 8.1 | 3.1 | 6.5 | 188.0 | 169 | 105 | 97 | 18 | 65 | 135 | 0 | 0 | 0 | 0 | 16 | 2 | 8 | 3.88 |
| SP | Marichal, J.Marichal, Juan SF >> | 31 | 1968 | R | 80 | 32 | 32 | 13 | 14 | 4.20 | .304 | 1.30 | 9.8 | 1.9 | 5.2 | 201.2 | 219 | 97 | 94 | 20 | 43 | 117 | 4 | 0 | 0 | 2 | 14 | 2 | 5 | 3.80 |
| SP | Schmidt, J.Schmidt, Jason SF >> | 31 | 2004 | R | 94 | 33 | 33 | 12 | 10 | 3.76 | .322 | 1.42 | 8.7 | 4.1 | 7.9 | 213.0 | 205 | 96 | 89 | 19 | 98 | 188 | 1 | 0 | 0 | 0 | 22 | 0 | 6 | 3.77 |
| CL | Wilson, B.Wilson, Brian SF >> | 27 | 2009 | R | 63 | 53 | 0 | 2 | 0 | 1.90 | .284 | 1.13 | 6.1 | 4.2 | 7.3 | 52.0 | 35 | 16 | 11 | 3 | 24 | 42 | 0 | 1 | 2 | 0 | 0 | 3 | 1 | 3.69 |
| RP | Lopez, J.Lopez, Javier SF >> | 38 | 2015 | L | 91 | 84 | 0 | 1 | 3 | 2.08 | .263 | 1.04 | 4.7 | 4.8 | 5.3 | 60.2 | 31 | 14 | 14 | 2 | 32 | 35 | 0 | 2 | 1 | 0 | 0 | 2 | 1 | 3.97 |
| RP | Romo, S.Romo, Sergio SF >> | 32 | 2015 | R | 70 | 81 | 0 | 3 | 2 | 3.12 | .270 | 1.11 | 8.0 | 2.1 | 9.1 | 69.1 | 61 | 29 | 24 | 2 | 16 | 70 | 0 | 0 | 1 | 0 | 0 | 0 | 6 | 2.04 |
| RP | Smith, W.Smith, Will SF >> | 28 | 2018 | L | 89 | 79 | 0 | 3 | 1 | 1.57 | .305 | 1.29 | 8.1 | 3.4 | 9.0 | 63.0 | 57 | 11 | 11 | 3 | 24 | 63 | 0 | 1 | 2 | 0 | 0 | 2 | 3 | 2.86 |
| RP | Wilhelm, H.Wilhelm, Hoyt SF >> | 47 | 1969 | R | 89 | 75 | 0 | 9 | 2 | 2.39 | .300 | 1.28 | 8.0 | 3.7 | 6.6 | 71.2 | 63 | 22 | 19 | 2 | 29 | 52 | 0 | 2 | 1 | 0 | 0 | 0 | 2 | 3.13 |
| RP | Nathan, J.Nathan, Joe SF # >> | 38 | 2012 | R | 74 | 59 | 0 | 3 | 9 | 5.18 | .348 | 1.57 | 11.5 | 2.7 | 9.4 | 64.1 | 82 | 38 | 37 | 5 | 19 | 67 | 0 | 32 | 9 | 0 | 0 | 2 | 1 | 2.91 |
| SP | Welch, M.Welch, Mickey SF >> | 31 | 1890 | R | 36 | 25 | 0 | 2 | 3 | 4.01 | .332 | 1.45 | 9.2 | 3.9 | 3.2 | 98.2 | 100 | 53 | 44 | 4 | 43 | 35 | 0 | 1 | 0 | 0 | 0 | 4 | 1 | 4.26 |