| SP | Bieber, S.Bieber, Shane CLE # >> | 30 | 2025 | R | 89 | 33 | 33 | 11 | 9 | 4.52 | .331 | 1.46 | 9.8 | 3.3 | 6.2 | 187.0 | 204 | 96 | 94 | 16 | 69 | 128 | 0 | 0 | 0 | 0 | 18 | 5 | 0 | 3.93 |
| SP | Score, H.Score, Herb CLE † >> | 24 | 1957 | L | 81 | 33 | 33 | 16 | 9 | 3.80 | .322 | 1.41 | 6.4 | 6.3 | 8.5 | 218.0 | 154 | 96 | 92 | 12 | 153 | 206 | 4 | 0 | 0 | 3 | 19 | 3 | 12 | 3.97 |
| SP | Bell, G.Bell, Gary CLE >> | 30 | 1966 | R | 80 | 32 | 32 | 14 | 9 | 3.61 | .298 | 1.26 | 8.0 | 3.3 | 4.8 | 214.1 | 190 | 96 | 86 | 22 | 79 | 114 | 2 | 0 | 0 | 2 | 17 | 4 | 3 | 4.43 |
| SP | Sabathia, C.Sabathia, CC CLE >> | 21 | 2001 | L | 55 | 32 | 32 | 13 | 7 | 3.77 | .300 | 1.28 | 6.8 | 4.8 | 5.8 | 181.2 | 136 | 83 | 76 | 16 | 96 | 117 | 0 | 0 | 0 | 0 | 13 | 2 | 3 | 4.48 |
| SP | Tiant, L.Tiant, Luis CLE >> | 41 | 1981 | R | 42 | 32 | 32 | 14 | 10 | 4.77 | .321 | 1.40 | 8.9 | 3.7 | 4.7 | 202.0 | 199 | 107 | 107 | 24 | 83 | 105 | 1 | 0 | 0 | 1 | 18 | 4 | 0 | 4.80 |
| RP | Smith, J.Smith, Joe CLE >> | 34 | 2018 | R | 83 | 84 | 0 | 6 | 5 | 3.30 | .316 | 1.35 | 8.8 | 3.4 | 7.1 | 103.2 | 101 | 42 | 38 | 10 | 39 | 81 | 0 | 1 | 5 | 0 | 0 | 4 | 0 | 3.94 |
| RP | Wilhelm, H.Wilhelm, Hoyt CLE >> | 41 | 1963 | R | 79 | 70 | 0 | 6 | 5 | 3.21 | .278 | 1.13 | 7.1 | 3.1 | 6.4 | 140.1 | 111 | 55 | 50 | 15 | 48 | 100 | 0 | 7 | 5 | 0 | 0 | 3 | 9 | 4.06 |
| RP | Rhodes, A.Rhodes, Arthur CLE # >> | 39 | 2008 | L | 57 | 57 | 0 | 3 | 2 | 3.79 | .321 | 1.42 | 7.9 | 4.9 | 8.7 | 59.1 | 52 | 27 | 25 | 3 | 32 | 57 | 0 | 2 | 3 | 0 | 0 | 0 | 2 | 3.36 |
| RP | LaRoche, D.LaRoche, Dave CLE >> | 33 | 1981 | L | 60 | 36 | 0 | 6 | 1 | 2.64 | .292 | 1.24 | 8.2 | 3.1 | 5.4 | 47.2 | 43 | 14 | 14 | 3 | 16 | 28 | 0 | 1 | 1 | 0 | 0 | 0 | 3 | 3.66 |
| RP | Shuey, P.Shuey, Paul CLE >> | 32 | 2002 | R | 49 | 23 | 0 | 2 | 1 | 5.47 | .357 | 1.66 | 8.3 | 7.1 | 4.9 | 24.2 | 22 | 15 | 15 | 1 | 19 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 4.83 |
| CL | Eckersley, D.Eckersley, Dennis CLE † >> | 37 | 1991 | R | 88 | 73 | 0 | 3 | 10 | 4.12 | .321 | 1.39 | 10.3 | 2.3 | 9.1 | 67.2 | 77 | 31 | 31 | 5 | 17 | 68 | 0 | 49 | 1 | 0 | 0 | 2 | 0 | 2.79 |