| SP | Richard, J.Richard, J.R. HOU >> | 26 | 1976 | R | 65 | 31 | 26 | 12 | 10 | 2.90 | .303 | 1.26 | 6.7 | 4.7 | 6.3 | 211.1 | 156 | 72 | 68 | 16 | 110 | 147 | 6 | 0 | 0 | 1 | 18 | 10 | 8 | 4.30 |
| SP | Ryan, N.Ryan, Nolan HOU >> | 35 | 1982 | R | 77 | 31 | 30 | 14 | 10 | 3.26 | .301 | 1.27 | 7.5 | 3.9 | 7.3 | 201.2 | 168 | 80 | 73 | 15 | 88 | 162 | 4 | 0 | 0 | 2 | 20 | 5 | 9 | 3.75 |
| SP | Scott, M.Scott, Mike HOU † >> | 34 | 1989 | R | 88 | 35 | 35 | 16 | 11 | 3.18 | .297 | 1.23 | 8.1 | 3.0 | 6.6 | 234.2 | 211 | 89 | 83 | 14 | 78 | 172 | 2 | 0 | 0 | 1 | 21 | 9 | 4 | 3.42 |
| SP | Niekro, J.Niekro, Joe HOU >> | 33 | 1977 | R | 60 | 32 | 25 | 5 | 5 | 3.60 | .312 | 1.35 | 8.0 | 4.1 | 5.9 | 130.0 | 116 | 56 | 52 | 8 | 59 | 85 | 0 | 0 | 0 | 0 | 1 | 2 | 5 | 3.90 |
| RP | Osuna, R.Osuna, Roberto HOU >> | 24 | 2019 | R | 95 | 93 | 0 | 4 | 3 | 1.39 | .218 | 0.81 | 6.0 | 1.3 | 10.6 | 97.0 | 65 | 15 | 15 | 4 | 14 | 114 | 0 | 5 | 1 | 0 | 0 | 2 | 1 | 1.68 |
| RP | Pressly, R.Pressly, Ryan HOU >> | 33 | 2022 | R | 98 | 89 | 0 | 7 | 4 | 1.63 | .227 | 0.87 | 4.7 | 3.1 | 9.8 | 83.0 | 43 | 17 | 15 | 2 | 29 | 90 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 2.23 |
| RP | Dawley, B.Dawley, Bill HOU >> | 25 | 1983 | R | 88 | 66 | 0 | 6 | 6 | 1.58 | .251 | 1.01 | 6.5 | 2.6 | 6.8 | 62.2 | 45 | 16 | 11 | 6 | 18 | 47 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 3.61 |
| RP | DiPino, F.DiPino, Frank HOU >> | 31 | 1987 | L | 31 | 84 | 0 | 3 | 3 | 2.30 | .285 | 1.19 | 7.4 | 3.4 | 5.9 | 58.2 | 48 | 21 | 15 | 6 | 22 | 38 | 0 | 0 | 3 | 0 | 0 | 0 | 4 | 4.17 |
| RP | Abad, F.Abad, Fernando HOU >> | 30 | 2016 | L | 40 | 78 | 0 | 3 | 3 | 2.77 | .308 | 1.32 | 8.1 | 3.9 | 6.6 | 48.2 | 43 | 15 | 15 | 3 | 21 | 35 | 0 | 2 | 0 | 0 | 0 | 1 | 1 | 3.73 |
| CL | Melancon, M.Melancon, Mark HOU >> | 36 | 2021 | R | 52 | 59 | 0 | 4 | 5 | 2.83 | .304 | 1.28 | 7.4 | 4.2 | 7.4 | 60.1 | 49 | 28 | 19 | 5 | 28 | 49 | 0 | 38 | 6 | 0 | 0 | 2 | 3 | 3.95 |
| SP | Schilling, C.Schilling, Curt HOU # >> | 32 | 1998 | R | 83 | 32 | 24 | 7 | 9 | 4.10 | .311 | 1.33 | 9.0 | 3.0 | 9.1 | 186.2 | 187 | 103 | 85 | 17 | 62 | 189 | 2 | 1 | 0 | 0 | 12 | 4 | 7 | 3.22 |
| SP | Oswalt, R.Oswalt, Roy HOU >> | 26 | 2003 | R | 72 | 33 | 29 | 10 | 9 | 4.91 | .328 | 1.42 | 9.9 | 2.9 | 7.2 | 163.0 | 179 | 100 | 89 | 13 | 53 | 131 | 1 | 1 | 0 | 1 | 14 | 7 | 2 | 3.53 |