| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 98 | 34 | 34 | 11 | 20 | 4.68 | .319 | 1.38 | 9.4 | 3.1 | 8.6 | 253.2 | 263 | 144 | 132 | 34 | 86 | 241 | 10 | 0 | 0 | 0 | 15 | 7 | 7 | 3.94 |
| SP | Adams, B.Adams, Babe # >> | 27 | 1909 | R | 86 | 33 | 33 | 10 | 10 | 5.15 | .326 | 1.44 | 10.3 | 2.7 | 4.9 | 176.2 | 201 | 104 | 101 | 32 | 53 | 95 | 0 | 0 | 0 | 0 | 10 | 2 | 1 | 5.22 |
| SP | Clemens, R.Clemens, Roger # >> | 24 | 1986 | R | 69 | 32 | 32 | 10 | 12 | 5.68 | .347 | 1.57 | 10.2 | 4.0 | 5.7 | 215.1 | 243 | 146 | 136 | 35 | 95 | 136 | 3 | 0 | 0 | 1 | 8 | 5 | 5 | 5.25 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 31 | 31 | 12 | 11 | 5.49 | .329 | 1.45 | 9.3 | 3.8 | 5.6 | 209.2 | 216 | 130 | 128 | 36 | 89 | 131 | 3 | 0 | 0 | 2 | 7 | 3 | 4 | 5.31 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 92 | 0 | 8 | 3 | 3.41 | .318 | 1.35 | 7.4 | 4.7 | 7.8 | 116.0 | 96 | 49 | 44 | 8 | 61 | 101 | 0 | 11 | 2 | 0 | 0 | 5 | 0 | 3.86 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 84 | 64 | 0 | 4 | 4 | 4.96 | .326 | 1.38 | 10.3 | 2.2 | 8.3 | 78.0 | 89 | 55 | 43 | 12 | 19 | 72 | 0 | 9 | 4 | 0 | 0 | 5 | 1 | 4.08 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 68 | 51 | 0 | 6 | 7 | 3.68 | .279 | 1.11 | 6.9 | 3.1 | 5.7 | 78.1 | 60 | 34 | 32 | 10 | 27 | 49 | 0 | 5 | 3 | 0 | 0 | 4 | 3 | 4.60 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 53 | 31 | 0 | 0 | 1 | 5.12 | .314 | 1.37 | 8.8 | 3.8 | 9.2 | 38.2 | 37 | 26 | 22 | 4 | 16 | 39 | 0 | 0 | 3 | 0 | 0 | 0 | 3 | 3.58 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 60 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 11 | 0 | 0 | 3 | 4.82 | .391 | 1.93 | 13.0 | 5.0 | 3.0 | 9.1 | 13 | 5 | 5 | 2 | 5 | 3 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 6.89 |