| SP | Koufax, S.Koufax, Sandy † $ >> | 30 | 1965 | L | 97 | 30 | 30 | 16 | 8 | 3.54 | .279 | 1.15 | 7.1 | 3.3 | 7.9 | 218.2 | 172 | 93 | 86 | 18 | 79 | 192 | 6 | 0 | 0 | 2 | 18 | 3 | 10 | 3.44 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 77 | 30 | 30 | 11 | 13 | 4.22 | .293 | 1.22 | 9.0 | 2.1 | 5.5 | 217.1 | 216 | 104 | 102 | 26 | 50 | 133 | 8 | 0 | 0 | 2 | 14 | 4 | 5 | 4.08 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 86 | 29 | 29 | 12 | 12 | 4.26 | .287 | 1.19 | 8.3 | 2.5 | 7.9 | 196.2 | 180 | 97 | 93 | 29 | 54 | 172 | 2 | 0 | 0 | 1 | 17 | 4 | 5 | 4.06 |
| CL | Jansen, K.Jansen, Kenley † >> | 28 | 2016 | R | 97 | 60 | 0 | 2 | 4 | 2.13 | .231 | 0.90 | 5.1 | 3.0 | 10.0 | 63.1 | 36 | 16 | 15 | 3 | 21 | 70 | 0 | 38 | 6 | 0 | 0 | 0 | 0 | 2.40 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 93 | 62 | 0 | 2 | 1 | 1.99 | .252 | 1.01 | 6.5 | 2.7 | 11.0 | 40.2 | 29 | 9 | 9 | 4 | 12 | 49 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 2.75 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 90 | 44 | 0 | 3 | 4 | 3.18 | .292 | 1.16 | 6.8 | 3.9 | 7.7 | 28.1 | 21 | 11 | 10 | 2 | 12 | 24 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 3.71 |
| RP | Brewer, J.Brewer, Jim # >> | 35 | 1972 | L | 73 | 72 | 0 | 3 | 1 | 5.18 | .349 | 1.58 | 10.5 | 4.0 | 5.7 | 41.2 | 48 | 27 | 24 | 10 | 18 | 26 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 6.29 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 85 | 22 | 0 | 5 | 2 | 3.10 | .274 | 1.13 | 7.7 | 2.7 | 9.5 | 20.1 | 17 | 9 | 7 | 3 | 6 | 21 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.75 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 19 | 1 | 1 | 1 | 5.29 | .338 | 1.50 | 10.0 | 3.7 | 3.8 | 64.2 | 71 | 38 | 38 | 5 | 26 | 27 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 4.48 |