| SP | Arrieta, J.Arrieta, Jake # $$ >> | 29 | 2015 | R | 93 | 20 | 20 | 8 | 7 | 4.04 | .320 | 1.39 | 9.8 | 2.7 | 9.1 | 131.1 | 143 | 70 | 59 | 14 | 39 | 132 | 0 | 0 | 0 | 0 | 12 | 3 | 4 | 3.34 |
| SP | Greinke, Z.Greinke, Zack # $$ >> | 32 | 2015 | R | 94 | 21 | 21 | 5 | 10 | 4.70 | .298 | 1.27 | 8.9 | 2.6 | 5.2 | 130.1 | 128 | 73 | 68 | 14 | 37 | 75 | 1 | 0 | 0 | 0 | 10 | 1 | 3 | 4.12 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 68 | 1 | 1 | 0 | 1 | 3.86 | .250 | 1.00 | 6.4 | 2.6 | 7.7 | 7.0 | 5 | 3 | 3 | 1 | 2 | 6 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 4.00 |
| SP | McLain, D.McLain, Denny # >> | 24 | 1968 | R | 79 | 20 | 20 | 7 | 11 | 4.70 | .307 | 1.30 | 9.3 | 2.4 | 5.1 | 138.0 | 143 | 80 | 72 | 17 | 37 | 78 | 6 | 0 | 0 | 1 | 10 | 3 | 3 | 4.34 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 74 | 16 | 14 | 6 | 6 | 4.50 | .360 | 1.64 | 10.7 | 4.1 | 4.1 | 102.0 | 121 | 67 | 51 | 15 | 46 | 47 | 0 | 0 | 0 | 0 | 9 | 5 | 1 | 5.49 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 66 | 24 | 0 | 0 | 0 | 1.72 | .282 | 1.15 | 7.3 | 3.2 | 7.3 | 31.1 | 25 | 6 | 6 | 0 | 11 | 25 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 2.55 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 27 | 0 | 2 | 1 | 3.45 | .289 | 1.22 | 8.7 | 2.6 | 5.8 | 28.2 | 27 | 13 | 11 | 2 | 8 | 18 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 3.50 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 73 | 14 | 0 | 0 | 1 | 5.65 | .368 | 1.74 | 7.7 | 8.4 | 9.0 | 14.1 | 12 | 10 | 9 | 0 | 13 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.79 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 26 | 0 | 2 | 2 | 3.76 | .301 | 1.25 | 8.0 | 3.5 | 12.1 | 26.1 | 23 | 11 | 11 | 4 | 10 | 35 | 0 | 14 | 3 | 0 | 0 | 1 | 0 | 3.58 |
| SP | Nola, A.Nola, Aaron # + >> | 25 | 2018 | R | 69 | 12 | 5 | 1 | 5 | 4.84 | .352 | 1.61 | 10.3 | 4.3 | 9.3 | 61.1 | 70 | 40 | 33 | 8 | 29 | 63 | 0 | 0 | 0 | 0 | 1 | 1 | 3 | 4.11 |