| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 32 | 32 | 16 | 5 | 2.30 | .234 | 0.91 | 5.9 | 2.3 | 9.0 | 227.1 | 150 | 66 | 58 | 22 | 58 | 226 | 0 | 0 | 0 | 0 | 30 | 0 | 0 | 3.04 |
| SP | Arrieta, J.Arrieta, Jake # >> | 29 | 2015 | R | 92 | 31 | 31 | 13 | 11 | 5.40 | .329 | 1.46 | 9.8 | 3.4 | 7.6 | 178.1 | 193 | 108 | 107 | 27 | 68 | 151 | 1 | 0 | 0 | 0 | 12 | 1 | 4 | 4.44 |
| SP | Sutton, D.Sutton, Don # >> | 27 | 1972 | R | 82 | 30 | 30 | 14 | 14 | 4.68 | .319 | 1.38 | 9.1 | 3.3 | 5.1 | 190.1 | 193 | 108 | 99 | 20 | 70 | 107 | 3 | 0 | 0 | 0 | 14 | 5 | 8 | 4.43 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 30 | 30 | 6 | 18 | 5.19 | .319 | 1.38 | 9.6 | 2.8 | 4.2 | 175.0 | 187 | 104 | 101 | 24 | 55 | 82 | 4 | 0 | 0 | 0 | 12 | 4 | 5 | 4.86 |
| CL | Kimbrel, C.Kimbrel, Craig † >> | 24 | 2012 | R | 100 | 74 | 0 | 4 | 3 | 2.80 | .283 | 1.17 | 7.6 | 3.0 | 10.0 | 83.2 | 70 | 26 | 26 | 5 | 28 | 92 | 0 | 40 | 1 | 0 | 0 | 1 | 4 | 2.61 |
| SU | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 80 | 0 | 3 | 1 | 2.75 | .273 | 1.12 | 6.6 | 3.4 | 9.4 | 95.0 | 70 | 32 | 29 | 7 | 36 | 99 | 0 | 2 | 3 | 0 | 0 | 1 | 2 | 3.04 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 90 | 0 | 9 | 3 | 3.42 | .318 | 1.39 | 10.4 | 2.1 | 8.9 | 97.1 | 112 | 40 | 37 | 7 | 23 | 96 | 0 | 3 | 2 | 0 | 0 | 1 | 0 | 2.70 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 66 | 0 | 1 | 7 | 4.72 | .335 | 1.49 | 9.4 | 4.1 | 8.6 | 68.2 | 71 | 38 | 36 | 14 | 31 | 65 | 0 | 2 | 1 | 0 | 0 | 2 | 7 | 5.22 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 80 | 51 | 0 | 3 | 2 | 4.84 | .302 | 1.30 | 8.7 | 3.0 | 7.3 | 67.0 | 65 | 37 | 36 | 9 | 22 | 54 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.12 |