| SP | Arrieta, J.Arrieta, Jake † $ >> | 29 | 2015 | R | 93 | 36 | 36 | 17 | 11 | 4.01 | .287 | 1.19 | 8.3 | 2.4 | 7.2 | 255.2 | 235 | 115 | 114 | 25 | 69 | 205 | 5 | 0 | 0 | 2 | 20 | 5 | 2 | 3.54 |
| SP | Leonard, D.Leonard, Dutch † $$ >> | 22 | 1914 | L | 91 | 35 | 35 | 20 | 9 | 3.08 | .284 | 1.18 | 7.5 | 3.1 | 5.1 | 240.0 | 201 | 87 | 82 | 24 | 83 | 137 | 4 | 0 | 0 | 2 | 24 | 2 | 2 | 4.22 |
| SP | Mathewson, C.Mathewson, Christy # >> | 28 | 1908 | R | 82 | 33 | 33 | 17 | 9 | 3.19 | .263 | 1.06 | 7.6 | 1.9 | 5.1 | 245.2 | 208 | 92 | 87 | 23 | 52 | 139 | 8 | 0 | 0 | 3 | 23 | 3 | 4 | 3.76 |
| SP | Maddux, G.Maddux, Greg $ >> | 29 | 1995 | R | 89 | 33 | 33 | 13 | 13 | 3.88 | .278 | 1.12 | 8.0 | 2.1 | 5.3 | 243.1 | 217 | 113 | 105 | 28 | 56 | 142 | 9 | 0 | 0 | 1 | 20 | 8 | 3 | 4.12 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 81 | 68 | 0 | 3 | 10 | 3.86 | .318 | 1.40 | 7.9 | 4.7 | 5.6 | 63.0 | 55 | 31 | 27 | 11 | 33 | 39 | 0 | 10 | 6 | 0 | 0 | 0 | 0 | 5.60 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 31 | 0 | 4 | 2 | 3.03 | .314 | 1.35 | 8.2 | 4.1 | 5.4 | 35.2 | 32 | 12 | 12 | 3 | 16 | 21 | 0 | 1 | 1 | 0 | 0 | 1 | 2 | 4.37 |
| RP | Eichhorn, M.Eichhorn, Mark >> | 26 | 1986 | R | 48 | 26 | 0 | 1 | 3 | 4.82 | .317 | 1.39 | 7.7 | 4.8 | 8.4 | 28.0 | 24 | 16 | 15 | 1 | 15 | 26 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 3.21 |
| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 84 | 21 | 0 | 2 | 1 | 5.03 | .308 | 1.34 | 9.1 | 2.9 | 8.6 | 68.0 | 69 | 42 | 38 | 11 | 22 | 65 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.16 |