| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 13 | 13 | 1 | 8 | 4.56 | .298 | 1.25 | 8.2 | 3.0 | 9.0 | 81.0 | 74 | 41 | 41 | 14 | 27 | 81 | 0 | 0 | 0 | 0 | 7 | 2 | 0 | 4.32 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 80 | 13 | 13 | 7 | 3 | 4.46 | .315 | 1.34 | 8.6 | 3.6 | 8.1 | 82.2 | 78 | 42 | 41 | 14 | 33 | 74 | 0 | 0 | 0 | 0 | 10 | 3 | 3 | 4.73 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 72 | 12 | 12 | 4 | 5 | 4.73 | .334 | 1.48 | 10.0 | 3.4 | 4.6 | 72.1 | 80 | 43 | 38 | 8 | 27 | 37 | 1 | 0 | 0 | 0 | 7 | 2 | 1 | 4.63 |
| CL | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 98 | 29 | 0 | 1 | 3 | 3.38 | .262 | 1.06 | 6.2 | 3.4 | 9.3 | 32.0 | 22 | 12 | 12 | 1 | 12 | 33 | 0 | 18 | 1 | 0 | 0 | 0 | 0 | 2.47 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 37 | 0 | 1 | 0 | 3.33 | .277 | 1.11 | 7.3 | 2.7 | 10.7 | 27.0 | 22 | 11 | 10 | 1 | 8 | 32 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2.11 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 22 | 0 | 2 | 1 | 6.08 | .355 | 1.65 | 8.3 | 6.9 | 13.2 | 13.1 | 12 | 10 | 9 | 3 | 10 | 19 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 5.38 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 11 | 0 | 1 | 0 | 1.74 | .225 | 0.87 | 3.6 | 4.5 | 11.7 | 10.1 | 4 | 2 | 2 | 0 | 5 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.90 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 6 | 0 | 1 | 0 | 1.80 | .318 | 1.40 | 5.4 | 7.2 | 10.8 | 5.0 | 3 | 2 | 1 | 0 | 4 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.00 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 64 | 40 | 0 | 1 | 0 | 1.26 | .295 | 1.26 | 8.0 | 3.5 | 9.3 | 28.2 | 25 | 7 | 4 | 1 | 11 | 29 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2.57 |
| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 43 | 8 | 0 | 0 | 1 | 6.59 | .414 | 2.09 | 12.7 | 6.3 | 4.3 | 27.1 | 38 | 21 | 20 | 3 | 19 | 13 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 5.70 |