| SP | Skubal, T.Skubal, Tarik † >> | 28 | 2025 | L | 100 | 23 | 23 | 10 | 3 | 2.48 | .275 | 1.10 | 7.2 | 2.7 | 9.9 | 156.1 | 125 | 46 | 43 | 9 | 47 | 172 | 0 | 0 | 0 | 0 | 18 | 6 | 1 | 2.56 |
| SP | Glasnow, T.Glasnow, Tyler >> | 31 | 2025 | R | 88 | 22 | 22 | 8 | 7 | 3.18 | .290 | 1.19 | 6.3 | 4.4 | 9.6 | 116.0 | 81 | 42 | 41 | 10 | 57 | 124 | 0 | 0 | 0 | 0 | 8 | 4 | 6 | 3.56 |
| SP | Nelson, R.Nelson, Ryne >> | 27 | 2025 | R | 81 | 21 | 21 | 3 | 8 | 6.59 | .369 | 1.72 | 11.5 | 4.0 | 8.7 | 82.0 | 105 | 60 | 60 | 15 | 36 | 79 | 0 | 0 | 0 | 0 | 2 | 3 | 1 | 4.88 |
| RP | Keller, B.Keller, Brad >> | 29 | 2025 | R | 91 | 54 | 0 | 1 | 4 | 3.19 | .319 | 1.37 | 9.0 | 3.5 | 9.4 | 67.2 | 67 | 25 | 24 | 4 | 26 | 70 | 0 | 3 | 4 | 0 | 0 | 2 | 4 | 2.94 |
| RP | Munoz, A.Munoz, Andres >> | 26 | 2025 | R | 90 | 53 | 0 | 6 | 3 | 3.82 | .326 | 1.40 | 6.8 | 5.9 | 11.1 | 61.1 | 46 | 27 | 26 | 4 | 40 | 75 | 0 | 7 | 4 | 0 | 0 | 3 | 3 | 3.51 |
| RP | Kittredge, A.Kittredge, Andrew >> | 35 | 2025 | R | 83 | 43 | 0 | 5 | 3 | 5.19 | .329 | 1.47 | 10.4 | 2.9 | 8.6 | 50.1 | 58 | 30 | 29 | 6 | 16 | 48 | 0 | 5 | 5 | 0 | 0 | 0 | 2 | 3.60 |
| RP | Weaver, L.Weaver, Luke >> | 31 | 2025 | R | 83 | 29 | 0 | 2 | 4 | 3.52 | .324 | 1.40 | 7.5 | 5.4 | 12.0 | 30.2 | 25 | 12 | 12 | 4 | 18 | 40 | 0 | 7 | 4 | 0 | 0 | 1 | 0 | 3.97 |
| RP | Henriquez, R.Henriquez, Ronny >> | 25 | 2025 | R | 77 | 20 | 0 | 0 | 1 | 2.78 | .269 | 1.06 | 6.5 | 3.3 | 14.3 | 22.2 | 16 | 9 | 7 | 0 | 8 | 35 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1.05 |
| RP | Santillan, T.Santillan, Tony >> | 28 | 2025 | R | 71 | 24 | 0 | 2 | 2 | 5.67 | .341 | 1.56 | 10.3 | 3.7 | 10.0 | 27.0 | 31 | 17 | 17 | 4 | 11 | 30 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.93 |
| SP | Singer, B.Singer, Brady >> | 28 | 2025 | R | 63 | 21 | 0 | 4 | 3 | 5.82 | .349 | 1.55 | 11.2 | 2.8 | 7.8 | 85.0 | 106 | 55 | 55 | 18 | 26 | 74 | 0 | 0 | 0 | 0 | 0 | 5 | 1 | 5.11 |