| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 18 | 18 | 5 | 6 | 3.43 | .267 | 1.08 | 7.1 | 2.7 | 8.5 | 115.1 | 91 | 46 | 44 | 14 | 34 | 108 | 0 | 0 | 0 | 0 | 14 | 1 | 0 | 3.62 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 89 | 17 | 17 | 6 | 6 | 4.59 | .311 | 1.35 | 8.7 | 3.4 | 8.4 | 104.0 | 101 | 56 | 53 | 12 | 39 | 97 | 1 | 0 | 0 | 1 | 9 | 1 | 3 | 3.79 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 16 | 16 | 8 | 3 | 3.76 | .280 | 1.12 | 8.3 | 1.8 | 6.6 | 115.0 | 106 | 51 | 48 | 14 | 23 | 84 | 5 | 0 | 0 | 1 | 9 | 5 | 3 | 3.85 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 16 | 16 | 5 | 5 | 4.35 | .299 | 1.26 | 7.5 | 3.8 | 6.9 | 93.0 | 78 | 46 | 45 | 14 | 39 | 71 | 0 | 0 | 0 | 0 | 11 | 2 | 1 | 4.75 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 46 | 0 | 6 | 1 | 4.38 | .294 | 1.20 | 8.1 | 2.8 | 10.0 | 61.2 | 55 | 30 | 30 | 6 | 19 | 68 | 0 | 5 | 1 | 0 | 0 | 3 | 0 | 3.13 |
| RP | Miller, A.Miller, Andrew † >> | 31 | 2016 | L | 91 | 45 | 0 | 5 | 1 | 1.91 | .213 | 0.79 | 5.5 | 1.8 | 8.7 | 56.2 | 34 | 13 | 12 | 6 | 11 | 54 | 0 | 5 | 0 | 0 | 0 | 1 | 0 | 3.11 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 30 | 0 | 2 | 4 | 3.62 | .345 | 1.58 | 11.5 | 2.8 | 7.0 | 32.1 | 41 | 16 | 13 | 7 | 10 | 25 | 0 | 3 | 1 | 0 | 0 | 0 | 1 | 5.22 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 74 | 26 | 0 | 1 | 4 | 5.96 | .369 | 1.68 | 7.9 | 7.6 | 8.3 | 25.2 | 22 | 18 | 17 | 4 | 21 | 23 | 0 | 0 | 4 | 0 | 0 | 2 | 5 | 6.00 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 71 | 20 | 0 | 2 | 1 | 4.66 | .318 | 1.40 | 9.0 | 3.8 | 8.1 | 19.1 | 19 | 10 | 10 | 6 | 8 | 17 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 6.58 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 67 | 13 | 0 | 1 | 0 | 2.70 | .296 | 1.20 | 7.3 | 3.9 | 6.2 | 16.2 | 13 | 5 | 5 | 2 | 7 | 11 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.75 |