| SP | Johnson, W.Johnson, Walter >> | 26 | 1913 | R | 95 | 38 | 38 | 17 | 16 | 3.29 | .291 | 1.22 | 9.1 | 1.9 | 4.9 | 306.2 | 308 | 124 | 112 | 19 | 66 | 166 | 17 | 0 | 0 | 3 | 25 | 4 | 1 | 3.41 |
| SP | Scherzer, M.Scherzer, Max # >> | 33 | 2017 | R | 95 | 35 | 35 | 12 | 17 | 5.36 | .333 | 1.46 | 9.3 | 3.9 | 9.7 | 241.2 | 249 | 145 | 144 | 30 | 104 | 259 | 3 | 0 | 0 | 0 | 14 | 9 | 10 | 3.88 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 34 | 34 | 15 | 10 | 4.13 | .303 | 1.27 | 8.2 | 3.2 | 5.6 | 239.2 | 218 | 119 | 110 | 27 | 86 | 150 | 3 | 0 | 0 | 0 | 21 | 9 | 5 | 4.41 |
| SP | McLain, D.McLain, Denny # >> | 24 | 1968 | R | 79 | 34 | 34 | 17 | 12 | 4.24 | .301 | 1.27 | 9.0 | 2.4 | 5.4 | 248.1 | 249 | 127 | 117 | 28 | 66 | 150 | 6 | 0 | 0 | 0 | 19 | 6 | 6 | 4.13 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 31 | 31 | 8 | 9 | 4.85 | .326 | 1.43 | 9.0 | 3.8 | 6.5 | 182.0 | 183 | 108 | 98 | 21 | 77 | 132 | 0 | 0 | 0 | 0 | 13 | 4 | 1 | 4.38 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 76 | 0 | 5 | 4 | 2.95 | .276 | 1.09 | 5.8 | 4.0 | 7.3 | 94.2 | 61 | 37 | 31 | 6 | 42 | 76 | 0 | 0 | 4 | 0 | 0 | 5 | 17 | 3.71 |
| RP | Benitez, A.Benitez, Armando # >> | 32 | 2004 | R | 82 | 48 | 0 | 5 | 5 | 4.28 | .302 | 1.28 | 7.5 | 4.2 | 6.8 | 54.2 | 45 | 26 | 26 | 7 | 25 | 41 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 4.61 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 43 | 0 | 7 | 2 | 4.24 | .327 | 1.41 | 7.6 | 5.3 | 9.0 | 46.2 | 39 | 23 | 22 | 7 | 27 | 46 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 4.87 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 92 | 26 | 0 | 0 | 0 | 4.94 | .354 | 1.61 | 11.7 | 3.0 | 7.7 | 27.1 | 35 | 16 | 15 | 2 | 9 | 23 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 3.37 |
| CL | Wagner, B.Wagner, Billy † >> | 28 | 1999 | L | 95 | 61 | 0 | 4 | 2 | 2.21 | .293 | 1.23 | 7.8 | 3.2 | 8.4 | 61.0 | 53 | 17 | 15 | 2 | 22 | 57 | 0 | 50 | 7 | 0 | 0 | 1 | 1 | 2.69 |