| SP | Johnson, W.Johnson, Walter >> | 26 | 1913 | R | 95 | 11 | 11 | 6 | 4 | 3.00 | .304 | 1.29 | 9.4 | 2.2 | 4.4 | 90.0 | 94 | 36 | 30 | 6 | 22 | 44 | 6 | 0 | 0 | 0 | 8 | 2 | 0 | 3.69 |
| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 10 | 10 | 4 | 2 | 5.24 | .344 | 1.53 | 10.2 | 3.7 | 8.7 | 68.2 | 77 | 40 | 40 | 10 | 28 | 66 | 1 | 0 | 0 | 0 | 4 | 3 | 1 | 4.34 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 11 | 11 | 4 | 3 | 3.42 | .257 | 1.00 | 6.5 | 2.5 | 6.4 | 79.0 | 57 | 32 | 30 | 9 | 22 | 56 | 0 | 0 | 0 | 0 | 7 | 3 | 0 | 4.01 |
| SP | McLain, D.McLain, Denny # >> | 24 | 1968 | R | 78 | 11 | 11 | 5 | 4 | 3.48 | .287 | 1.17 | 8.6 | 2.0 | 5.6 | 85.1 | 81 | 37 | 33 | 10 | 19 | 53 | 3 | 0 | 0 | 0 | 7 | 3 | 0 | 4.06 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 11 | 11 | 2 | 3 | 6.31 | .358 | 1.63 | 11.1 | 3.8 | 6.2 | 55.2 | 68 | 42 | 39 | 8 | 23 | 38 | 0 | 0 | 0 | 0 | 4 | 2 | 1 | 4.87 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 23 | 0 | 3 | 1 | 1.76 | .240 | 0.85 | 4.2 | 3.6 | 7.5 | 30.2 | 14 | 9 | 6 | 0 | 12 | 25 | 0 | 0 | 1 | 0 | 0 | 3 | 6 | 2.83 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 81 | 20 | 0 | 1 | 3 | 5.12 | .326 | 1.45 | 8.1 | 5.2 | 7.1 | 19.1 | 17 | 11 | 11 | 3 | 11 | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.21 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 69 | 11 | 0 | 3 | 0 | 5.11 | .351 | 1.62 | 9.8 | 5.3 | 7.5 | 12.1 | 13 | 7 | 7 | 2 | 7 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5.25 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 91 | 9 | 0 | 0 | 0 | 9.00 | .423 | 2.10 | 15.3 | 3.6 | 9.0 | 10.0 | 17 | 11 | 10 | 2 | 4 | 10 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5.10 |
| CL | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 21 | 0 | 1 | 2 | 3.26 | .318 | 1.40 | 8.1 | 4.7 | 8.1 | 19.1 | 17 | 7 | 7 | 0 | 10 | 17 | 0 | 17 | 3 | 0 | 0 | 0 | 0 | 2.79 |