| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 34 | 34 | 20 | 6 | 3.24 | .291 | 1.21 | 7.8 | 3.1 | 9.3 | 216.1 | 187 | 83 | 78 | 21 | 75 | 224 | 1 | 0 | 0 | 1 | 21 | 4 | 0 | 3.29 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 33 | 33 | 9 | 18 | 4.87 | .308 | 1.32 | 8.9 | 2.9 | 4.5 | 242.0 | 240 | 139 | 131 | 30 | 79 | 120 | 4 | 0 | 0 | 1 | 15 | 4 | 8 | 4.65 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 68 | 32 | 32 | 11 | 15 | 5.08 | .327 | 1.43 | 9.6 | 3.3 | 6.3 | 237.1 | 253 | 137 | 134 | 32 | 86 | 165 | 9 | 0 | 0 | 1 | 13 | 7 | 6 | 4.54 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 61 | 32 | 31 | 9 | 12 | 5.66 | .345 | 1.56 | 8.8 | 5.3 | 7.8 | 173.1 | 169 | 112 | 109 | 20 | 102 | 150 | 0 | 0 | 0 | 0 | 14 | 3 | 2 | 4.59 |
| SP | Hudson, D.Hudson, Daniel # >> | 23 | 2010 | R | 60 | 31 | 31 | 10 | 14 | 5.15 | .329 | 1.42 | 9.8 | 3.1 | 5.9 | 190.2 | 206 | 114 | 109 | 26 | 65 | 124 | 2 | 0 | 0 | 1 | 15 | 9 | 10 | 4.64 |
| RP | Rivera, M.Rivera, Mariano # >> | 39 | 2008 | R | 85 | 82 | 0 | 4 | 6 | 4.34 | .313 | 1.35 | 10.0 | 2.2 | 8.5 | 103.2 | 115 | 50 | 50 | 18 | 25 | 97 | 0 | 11 | 6 | 0 | 0 | 2 | 3 | 4.17 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 67 | 66 | 0 | 2 | 3 | 4.27 | .322 | 1.41 | 8.7 | 4.0 | 9.6 | 65.1 | 63 | 32 | 31 | 7 | 29 | 69 | 0 | 7 | 1 | 0 | 0 | 1 | 5 | 3.66 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 60 | 55 | 0 | 4 | 4 | 4.11 | .318 | 1.39 | 9.3 | 3.3 | 8.2 | 65.2 | 67 | 31 | 30 | 8 | 24 | 59 | 0 | 3 | 4 | 0 | 0 | 1 | 1 | 3.94 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 24 | 0 | 1 | 4 | 6.54 | .383 | 1.83 | 12.8 | 4.1 | 7.5 | 31.2 | 44 | 23 | 23 | 6 | 14 | 26 | 0 | 4 | 0 | 0 | 0 | 1 | 2 | 5.29 |