| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 26 | 26 | 11 | 10 | 3.23 | .252 | 0.99 | 6.6 | 2.4 | 9.1 | 175.1 | 128 | 64 | 63 | 22 | 46 | 176 | 1 | 0 | 0 | 1 | 15 | 3 | 0 | 3.46 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 23 | 23 | 7 | 13 | 4.63 | .328 | 1.43 | 9.6 | 3.4 | 7.1 | 155.2 | 165 | 82 | 80 | 14 | 58 | 122 | 1 | 0 | 0 | 0 | 11 | 5 | 4 | 3.82 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 79 | 24 | 24 | 10 | 10 | 4.43 | .305 | 1.31 | 9.2 | 2.6 | 4.8 | 168.2 | 172 | 84 | 83 | 26 | 49 | 89 | 4 | 0 | 0 | 1 | 11 | 1 | 1 | 4.85 |
| SP | Fernandez, J.Fernandez, Jose # >> | 21 | 2013 | R | 76 | 24 | 24 | 11 | 7 | 3.78 | .283 | 1.18 | 8.1 | 2.6 | 8.4 | 154.2 | 138 | 70 | 65 | 17 | 44 | 144 | 0 | 0 | 0 | 0 | 13 | 1 | 1 | 3.44 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 49 | 24 | 24 | 10 | 6 | 3.63 | .305 | 1.29 | 7.2 | 4.5 | 7.5 | 158.2 | 126 | 65 | 64 | 13 | 79 | 131 | 1 | 0 | 0 | 1 | 17 | 4 | 3 | 3.99 |
| CL | Wagner, B.Wagner, Billy † >> | 28 | 1999 | L | 95 | 46 | 0 | 1 | 4 | 2.22 | .283 | 1.19 | 7.0 | 3.9 | 10.0 | 44.2 | 34 | 11 | 11 | 4 | 19 | 49 | 0 | 33 | 2 | 0 | 0 | 0 | 0 | 3.25 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 62 | 0 | 6 | 2 | 2.97 | .248 | 0.96 | 6.8 | 2.0 | 7.4 | 69.2 | 52 | 23 | 23 | 11 | 15 | 57 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 4.16 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 25 | 0 | 1 | 2 | 4.10 | .336 | 1.48 | 7.6 | 5.9 | 7.3 | 26.1 | 22 | 12 | 12 | 3 | 17 | 21 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.96 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 12 | 0 | 1 | 0 | 2.53 | .256 | 1.03 | 7.2 | 2.7 | 7.2 | 10.2 | 8 | 3 | 3 | 2 | 3 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.90 |
| RP | Niedenfuer, T.Niedenfuer, Tom >> | 24 | 1983 | R | 62 | 12 | 0 | 0 | 0 | 1.15 | .242 | 0.96 | 6.0 | 3.0 | 2.4 | 15.2 | 10 | 2 | 2 | 0 | 5 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.47 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 63 | 16 | 0 | 3 | 0 | 4.26 | .224 | 0.87 | 4.5 | 3.8 | 14.3 | 12.2 | 6 | 6 | 6 | 2 | 5 | 19 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.25 |