| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 20 | 20 | 8 | 3 | 3.64 | .277 | 1.13 | 7.7 | 2.5 | 9.8 | 128.2 | 110 | 54 | 52 | 14 | 35 | 140 | 0 | 0 | 0 | 0 | 16 | 3 | 0 | 3.13 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 19 | 19 | 7 | 7 | 5.64 | .335 | 1.50 | 11.0 | 2.4 | 7.0 | 107.0 | 131 | 69 | 67 | 24 | 29 | 83 | 0 | 0 | 0 | 0 | 6 | 2 | 3 | 5.23 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 72 | 20 | 19 | 4 | 6 | 4.26 | .297 | 1.25 | 8.2 | 3.1 | 5.5 | 124.2 | 113 | 61 | 59 | 12 | 43 | 76 | 1 | 0 | 0 | 0 | 11 | 2 | 2 | 4.12 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 51 | 0 | 5 | 5 | 3.97 | .287 | 1.18 | 5.8 | 4.9 | 11.1 | 70.1 | 45 | 38 | 31 | 6 | 38 | 86 | 0 | 3 | 4 | 0 | 0 | 2 | 10 | 3.37 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 85 | 51 | 0 | 4 | 3 | 3.40 | .321 | 1.40 | 8.0 | 4.7 | 8.2 | 55.2 | 49 | 22 | 21 | 3 | 29 | 50 | 0 | 8 | 1 | 0 | 0 | 1 | 3 | 3.53 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 32 | 0 | 1 | 3 | 3.57 | .289 | 1.22 | 6.4 | 4.6 | 9.0 | 35.1 | 25 | 15 | 14 | 3 | 18 | 35 | 0 | 9 | 5 | 0 | 0 | 0 | 0 | 3.66 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 80 | 21 | 0 | 2 | 3 | 6.46 | .297 | 1.27 | 8.6 | 3.1 | 10.6 | 23.2 | 22 | 17 | 17 | 3 | 8 | 27 | 0 | 2 | 2 | 0 | 0 | 0 | 1 | 3.39 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 17 | 0 | 0 | 1 | 5.30 | .325 | 1.45 | 6.5 | 7.0 | 11.0 | 18.2 | 13 | 11 | 11 | 3 | 14 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.06 |