| SP | Mathewson, C.Mathewson, Christy $ >> | 28 | 1908 | R | 82 | 33 | 32 | 16 | 9 | 3.61 | .277 | 1.14 | 8.3 | 2.0 | 4.7 | 217.0 | 200 | 92 | 87 | 19 | 48 | 113 | 4 | 0 | 0 | 1 | 19 | 1 | 2 | 3.77 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 32 | 30 | 10 | 15 | 4.98 | .332 | 1.48 | 9.6 | 3.7 | 5.9 | 173.1 | 185 | 116 | 96 | 29 | 72 | 114 | 1 | 0 | 0 | 0 | 15 | 1 | 5 | 5.13 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 91 | 0 | 5 | 3 | 4.72 | .304 | 1.30 | 9.0 | 2.7 | 9.0 | 95.1 | 95 | 57 | 50 | 16 | 29 | 95 | 0 | 0 | 2 | 0 | 0 | 1 | 4 | 4.14 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 79 | 0 | 6 | 4 | 4.58 | .324 | 1.40 | 9.0 | 3.7 | 10.4 | 88.1 | 88 | 46 | 45 | 13 | 36 | 102 | 0 | 1 | 2 | 0 | 0 | 3 | 0 | 3.93 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 63 | 0 | 3 | 2 | 4.11 | .286 | 1.19 | 7.6 | 3.2 | 7.9 | 76.2 | 64 | 35 | 35 | 13 | 27 | 67 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 4.57 |
| CL | Wagner, B.Wagner, Billy † $ >> | 28 | 1999 | L | 95 | 75 | 0 | 5 | 6 | 2.19 | .288 | 1.21 | 7.2 | 3.7 | 9.8 | 82.1 | 66 | 23 | 20 | 3 | 34 | 89 | 0 | 36 | 5 | 0 | 0 | 0 | 2 | 2.55 |
| SU | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 79 | 0 | 5 | 4 | 2.86 | .267 | 1.07 | 7.4 | 2.2 | 8.6 | 85.0 | 70 | 30 | 27 | 7 | 21 | 81 | 0 | 5 | 8 | 0 | 0 | 2 | 2 | 2.98 |