| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 29 | 29 | 8 | 14 | 4.88 | .326 | 1.44 | 9.5 | 3.5 | 8.2 | 190.0 | 200 | 115 | 103 | 33 | 74 | 173 | 2 | 0 | 0 | 0 | 12 | 2 | 6 | 4.64 |
| SP | Richard, J.Richard, J.R. >> | 30 | 1980 | R | 90 | 28 | 28 | 12 | 8 | 3.75 | .308 | 1.32 | 7.4 | 4.5 | 7.2 | 175.0 | 144 | 81 | 73 | 12 | 87 | 140 | 2 | 0 | 0 | 0 | 15 | 3 | 4 | 3.83 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 82 | 28 | 28 | 9 | 8 | 4.10 | .285 | 1.17 | 8.0 | 2.6 | 5.8 | 182.1 | 162 | 91 | 83 | 23 | 52 | 118 | 4 | 0 | 0 | 0 | 16 | 4 | 5 | 4.27 |
| SP | Clemens, R.Clemens, Roger # >> | 24 | 1986 | R | 69 | 31 | 26 | 8 | 10 | 6.59 | .383 | 1.83 | 12.2 | 4.4 | 6.8 | 140.2 | 189 | 113 | 103 | 25 | 69 | 106 | 1 | 0 | 0 | 0 | 10 | 4 | 7 | 5.37 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 78 | 0 | 2 | 5 | 5.57 | .348 | 1.59 | 8.5 | 5.9 | 7.9 | 85.2 | 80 | 57 | 53 | 10 | 56 | 75 | 0 | 3 | 4 | 0 | 0 | 1 | 2 | 4.78 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 66 | 0 | 6 | 3 | 5.52 | .335 | 1.51 | 8.8 | 4.9 | 8.5 | 73.1 | 71 | 46 | 45 | 12 | 40 | 69 | 0 | 0 | 3 | 0 | 0 | 0 | 7 | 4.89 |
| RP | Dotel, O.Dotel, Octavio $ >> | 29 | 2002 | R | 68 | 52 | 0 | 2 | 4 | 4.35 | .314 | 1.32 | 9.2 | 2.8 | 8.6 | 51.2 | 52 | 28 | 25 | 9 | 16 | 49 | 0 | 2 | 2 | 0 | 0 | 3 | 0 | 4.49 |
| SU | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 53 | 0 | 0 | 1 | 4.30 | .320 | 1.40 | 9.6 | 3.1 | 9.0 | 58.2 | 62 | 32 | 28 | 6 | 20 | 58 | 0 | 1 | 4 | 0 | 0 | 1 | 0 | 3.43 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 39 | 0 | 2 | 1 | 4.44 | .309 | 1.30 | 9.5 | 2.3 | 9.2 | 50.2 | 53 | 25 | 25 | 5 | 13 | 51 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 3.16 |
| CL | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 58 | 0 | 4 | 10 | 4.21 | .298 | 1.24 | 7.4 | 3.8 | 9.8 | 68.1 | 56 | 36 | 32 | 16 | 29 | 74 | 0 | 22 | 9 | 0 | 0 | 2 | 0 | 5.25 |