| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 33 | 33 | 15 | 13 | 3.97 | .291 | 1.20 | 8.2 | 2.6 | 8.0 | 224.1 | 205 | 109 | 99 | 33 | 65 | 198 | 3 | 0 | 0 | 3 | 21 | 6 | 0 | 4.10 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 76 | 32 | 32 | 9 | 16 | 4.89 | .304 | 1.30 | 9.2 | 2.5 | 5.1 | 230.0 | 234 | 142 | 125 | 36 | 64 | 131 | 12 | 0 | 0 | 0 | 12 | 4 | 1 | 4.78 |
| RP | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 99 | 78 | 0 | 11 | 5 | 4.28 | .261 | 1.02 | 6.9 | 2.4 | 8.7 | 107.1 | 82 | 52 | 51 | 7 | 28 | 104 | 0 | 9 | 4 | 0 | 0 | 4 | 5 | 2.80 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 80 | 0 | 5 | 2 | 3.83 | .300 | 1.28 | 8.6 | 2.9 | 6.7 | 87.0 | 83 | 37 | 37 | 13 | 28 | 65 | 0 | 8 | 2 | 0 | 0 | 1 | 0 | 4.45 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 81 | 50 | 0 | 1 | 1 | 2.90 | .303 | 1.27 | 7.2 | 4.3 | 5.6 | 59.0 | 47 | 23 | 19 | 4 | 28 | 37 | 0 | 7 | 2 | 0 | 0 | 2 | 0 | 4.15 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 36 | 0 | 3 | 4 | 5.32 | .328 | 1.47 | 9.2 | 4.2 | 3.4 | 45.2 | 46 | 27 | 27 | 11 | 21 | 17 | 0 | 2 | 2 | 0 | 0 | 0 | 1 | 6.82 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 15 | 0 | 1 | 1 | 4.43 | .358 | 1.62 | 9.0 | 5.9 | 7.2 | 20.1 | 20 | 10 | 10 | 2 | 13 | 16 | 0 | 2 | 1 | 0 | 0 | 1 | 1 | 4.80 |