| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 14 | 14 | 4 | 8 | 5.14 | .327 | 1.44 | 8.9 | 4.1 | 9.4 | 77.0 | 76 | 48 | 44 | 7 | 35 | 80 | 0 | 0 | 0 | 0 | 7 | 1 | 4 | 3.51 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 14 | 14 | 5 | 5 | 4.74 | .342 | 1.53 | 10.4 | 3.5 | 9.8 | 79.2 | 91 | 43 | 42 | 16 | 31 | 86 | 0 | 0 | 0 | 0 | 7 | 2 | 4 | 4.71 |
| SP | Hunter, C.Hunter, Catfish # >> | 26 | 1972 | R | 82 | 14 | 14 | 6 | 7 | 4.71 | .303 | 1.28 | 9.5 | 2.1 | 6.9 | 93.2 | 98 | 54 | 49 | 21 | 22 | 71 | 1 | 0 | 0 | 0 | 7 | 2 | 1 | 5.18 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 13 | 13 | 4 | 5 | 7.07 | .357 | 1.67 | 11.5 | 3.6 | 3.6 | 62.1 | 79 | 51 | 49 | 10 | 25 | 25 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 5.50 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 15 | 13 | 4 | 4 | 6.17 | .357 | 1.64 | 11.2 | 3.6 | 5.7 | 77.1 | 96 | 58 | 53 | 16 | 31 | 49 | 0 | 0 | 0 | 0 | 4 | 2 | 1 | 5.71 |
| CL | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 96 | 33 | 0 | 2 | 2 | 5.04 | .381 | 1.78 | 8.7 | 7.5 | 7.8 | 30.1 | 29 | 17 | 17 | 5 | 25 | 26 | 0 | 18 | 1 | 0 | 0 | 2 | 0 | 6.13 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 90 | 32 | 0 | 1 | 1 | 4.85 | .324 | 1.44 | 8.1 | 4.8 | 7.4 | 39.0 | 35 | 22 | 21 | 4 | 21 | 32 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.31 |
| SU | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 27 | 0 | 1 | 2 | 6.56 | .327 | 1.41 | 10.6 | 2.3 | 6.7 | 23.1 | 27 | 17 | 17 | 5 | 6 | 17 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 5.26 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 24 | 0 | 2 | 0 | 4.11 | .292 | 1.24 | 8.1 | 3.3 | 8.7 | 30.2 | 27 | 16 | 14 | 4 | 11 | 29 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.90 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 73 | 20 | 0 | 1 | 0 | 5.68 | .329 | 1.47 | 9.9 | 3.3 | 9.0 | 19.0 | 21 | 13 | 12 | 7 | 7 | 19 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 6.89 |