| SP | Scherzer, M.Scherzer, Max † >> | 33 | 2017 | R | 95 | 33 | 33 | 9 | 18 | 4.14 | .311 | 1.34 | 8.5 | 3.6 | 8.4 | 213.0 | 200 | 114 | 98 | 29 | 86 | 199 | 1 | 0 | 0 | 1 | 19 | 3 | 9 | 4.15 |
| SP | Adams, B.Adams, Babe # >> | 27 | 1909 | R | 86 | 33 | 33 | 9 | 12 | 4.64 | .329 | 1.45 | 9.8 | 3.3 | 4.3 | 170.2 | 186 | 99 | 88 | 20 | 62 | 81 | 0 | 0 | 0 | 0 | 9 | 3 | 3 | 4.72 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 32 | 32 | 8 | 10 | 4.45 | .328 | 1.44 | 9.8 | 3.2 | 4.5 | 198.0 | 216 | 104 | 98 | 32 | 70 | 99 | 4 | 0 | 0 | 1 | 17 | 4 | 3 | 5.22 |
| SP | Tudor, J.Tudor, John # >> | 31 | 1985 | L | 63 | 31 | 31 | 10 | 18 | 4.67 | .320 | 1.38 | 9.6 | 2.9 | 4.5 | 206.0 | 219 | 117 | 107 | 29 | 66 | 103 | 5 | 0 | 0 | 2 | 12 | 6 | 2 | 4.88 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 95 | 85 | 0 | 8 | 4 | 3.26 | .271 | 1.07 | 7.1 | 2.5 | 9.1 | 121.1 | 96 | 48 | 44 | 11 | 34 | 123 | 0 | 4 | 1 | 0 | 0 | 5 | 1 | 3.12 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 61 | 0 | 5 | 5 | 3.26 | .302 | 1.28 | 7.0 | 4.5 | 5.5 | 99.1 | 77 | 38 | 36 | 8 | 50 | 61 | 0 | 7 | 2 | 0 | 0 | 2 | 2 | 4.39 |
| RP | Eichhorn, M.Eichhorn, Mark >> | 26 | 1986 | R | 48 | 47 | 0 | 2 | 5 | 2.63 | .280 | 1.08 | 7.1 | 2.6 | 8.8 | 72.0 | 57 | 22 | 21 | 11 | 21 | 70 | 0 | 4 | 1 | 0 | 0 | 6 | 2 | 4.17 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 61 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 56 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | McQuillan, G.McQuillan, George >> | 23 | 1908 | R | 48 | 1 | 0 | 0 | 0 | 0.00 | .000 | 0.00 | 0.0 | 0.0 | 0.0 | 1.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.00 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 58 | 7 | 0 | 0 | 1 | 7.00 | .372 | 1.67 | 11.0 | 4.0 | 2.0 | 9.0 | 11 | 7 | 7 | 1 | 4 | 2 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 5.67 |