| SP | Arrieta, J.Arrieta, Jake $ >> | 29 | 2015 | R | 93 | 34 | 34 | 15 | 10 | 3.81 | .273 | 1.09 | 7.3 | 2.6 | 7.7 | 201.0 | 163 | 91 | 85 | 15 | 57 | 171 | 1 | 0 | 0 | 0 | 19 | 6 | 6 | 3.21 |
| SP | Richard, J.Richard, J.R. >> | 30 | 1980 | R | 90 | 32 | 32 | 17 | 8 | 2.92 | .289 | 1.20 | 6.8 | 4.0 | 7.5 | 225.0 | 170 | 78 | 73 | 19 | 99 | 187 | 2 | 0 | 0 | 1 | 23 | 5 | 2 | 3.82 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 32 | 32 | 15 | 11 | 3.22 | .267 | 1.08 | 7.7 | 2.0 | 3.2 | 212.2 | 181 | 81 | 76 | 22 | 48 | 75 | 3 | 0 | 0 | 0 | 23 | 3 | 4 | 4.36 |
| SP | Fernandez, J.Fernandez, Jose # >> | 21 | 2013 | R | 76 | 32 | 32 | 14 | 7 | 3.37 | .300 | 1.26 | 7.3 | 4.1 | 8.5 | 205.2 | 167 | 85 | 77 | 19 | 93 | 194 | 2 | 0 | 0 | 1 | 21 | 4 | 9 | 3.73 |
| SP | Fernandez, S.Fernandez, Sid >> | 26 | 1988 | L | 50 | 31 | 31 | 17 | 10 | 4.83 | .325 | 1.41 | 8.4 | 4.3 | 6.9 | 179.0 | 167 | 99 | 96 | 25 | 85 | 137 | 0 | 0 | 0 | 0 | 12 | 6 | 5 | 4.81 |
| RP | Chapman, A.Chapman, Aroldis † >> | 26 | 2014 | L | 93 | 85 | 0 | 3 | 2 | 1.89 | .259 | 1.01 | 5.1 | 4.0 | 9.7 | 119.0 | 67 | 25 | 25 | 3 | 53 | 128 | 0 | 11 | 2 | 0 | 0 | 5 | 3 | 2.64 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 78 | 0 | 3 | 5 | 2.17 | .230 | 0.88 | 6.8 | 1.1 | 6.9 | 108.0 | 82 | 28 | 26 | 11 | 13 | 83 | 0 | 20 | 4 | 0 | 0 | 2 | 0 | 3.20 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 58 | 0 | 6 | 4 | 2.30 | .283 | 1.17 | 7.2 | 3.4 | 8.0 | 74.1 | 59 | 21 | 19 | 7 | 28 | 66 | 0 | 8 | 0 | 0 | 0 | 1 | 0 | 3.62 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 72 | 33 | 0 | 3 | 1 | 1.34 | .252 | 0.98 | 4.6 | 4.4 | 10.4 | 33.2 | 17 | 5 | 5 | 2 | 16 | 38 | 0 | 5 | 1 | 0 | 0 | 1 | 0 | 3.03 |
| RP | Radatz, D.Radatz, Dick # >> | 27 | 1964 | R | 37 | 38 | 0 | 5 | 1 | 4.85 | .320 | 1.41 | 7.9 | 4.9 | 7.3 | 68.2 | 60 | 37 | 37 | 11 | 37 | 55 | 0 | 2 | 0 | 0 | 0 | 0 | 4 | 5.12 |