| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 28 | 28 | 12 | 9 | 3.49 | .292 | 1.23 | 8.4 | 2.7 | 7.4 | 162.2 | 152 | 68 | 63 | 13 | 48 | 134 | 0 | 0 | 0 | 0 | 14 | 1 | 5 | 3.30 |
| SP | Snell, B.Snell, Blake # >> | 25 | 2018 | L | 80 | 29 | 29 | 15 | 4 | 3.38 | .263 | 1.05 | 6.4 | 3.1 | 8.2 | 173.0 | 123 | 66 | 65 | 20 | 59 | 157 | 0 | 0 | 0 | 0 | 16 | 3 | 7 | 3.76 |
| SP | Johnson, W.Johnson, Walter >> | 26 | 1913 | R | 95 | 28 | 28 | 14 | 7 | 3.15 | .253 | 1.00 | 7.7 | 1.3 | 4.9 | 191.1 | 164 | 68 | 67 | 20 | 28 | 103 | 3 | 0 | 0 | 1 | 18 | 2 | 2 | 3.75 |
| SP | Fernandez, J.Fernandez, Jose † >> | 21 | 2013 | R | 76 | 27 | 27 | 15 | 7 | 3.49 | .294 | 1.24 | 7.1 | 4.1 | 8.1 | 193.2 | 153 | 76 | 75 | 13 | 88 | 173 | 4 | 0 | 0 | 2 | 17 | 1 | 1 | 3.47 |
| SP | Santana, J.Santana, Johan † >> | 25 | 2004 | L | 86 | 28 | 27 | 12 | 8 | 3.29 | .267 | 1.07 | 7.1 | 2.5 | 7.3 | 224.0 | 176 | 86 | 82 | 18 | 63 | 181 | 13 | 0 | 0 | 3 | 19 | 6 | 2 | 3.35 |
| RP | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 98 | 74 | 0 | 7 | 2 | 2.55 | .250 | 0.98 | 6.3 | 2.5 | 8.5 | 99.0 | 69 | 31 | 28 | 11 | 28 | 94 | 0 | 13 | 3 | 0 | 0 | 2 | 0 | 3.45 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 55 | 0 | 0 | 4 | 2.71 | .243 | 0.90 | 5.5 | 2.7 | 10.2 | 69.2 | 42 | 21 | 21 | 7 | 21 | 78 | 0 | 13 | 0 | 0 | 0 | 4 | 2 | 3.14 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 40 | 0 | 8 | 0 | 1.52 | .207 | 0.78 | 4.6 | 2.5 | 9.8 | 47.1 | 24 | 8 | 8 | 2 | 13 | 51 | 0 | 3 | 1 | 0 | 0 | 0 | 2 | 2.21 |
| RP | Eichhorn, M.Eichhorn, Mark >> | 26 | 1986 | R | 48 | 30 | 0 | 3 | 2 | 4.07 | .321 | 1.39 | 6.8 | 5.7 | 8.3 | 66.1 | 50 | 30 | 30 | 5 | 42 | 61 | 0 | 1 | 0 | 0 | 0 | 2 | 5 | 4.14 |